Teratocarcinosarcoma is a rare and aggressive malignant tumor of uncertain histogenesis. It presents <1% of all cancers and ~3% of malignant tumors of the head and neck. It arises commonly from the nasal cavity and paranasal sinuses. To the best of our knowledge, only one case has been reported in the oral cavity. A 46-year-old woman presented with 3-week history of a rapidly growing tumor in the inner side of the left cheek. Physical examination revealed an ulcerating mass measuring 4 × 3.5 cm. An excisional biopsy was performed. Histological analysis revealed a teratocarcinosrcoma. The patient was treated by combined chemotherapy and radiation therapy. No recurrence was noted 6 months after treatment. The prognosis is poor.
Background: The coronavirus disease 2019 pandemic is an unprecedented situation. Mass vaccination is a considered a promising solution to combat this global health crisis. Different vaccine have used to control transmission of the disease. Some complications of this vaccine were reported including rare cases of vasculitis. We report a case of leucocytoclastic vasculitis following BNT162b2 corona virus vaccine. Case Presentation: A 42 year old man with no medical history or drug intake presented 3 days after the third dose of BNT162b2 vaccine an infiltrated purpura at the lower extremities, fever, asthenia and myalgia. At physical examination, multiple palpable indurated purpuric papules were present only on the lower extremities. Laboratory tests were normal. The skin biopsy revealed leucocytoclastic vasculitis. The direct immunofluorescence staining detected only fibrinogen deposition. Conclusion: Leucocytoclastic vasculitis is an exceptional vaccine side effect. The resemblance of the vaccine-induced spike proteins with human components is highly likely to produce pathological autoantibodies and vaccine-induced autoimmunity through molecular mimicry.
Dermal nonneural granular cell tumor is a rare neoplasm of uncertain histogenesis that Le Boit and colleagues originally described in 1991. It arises commonly from the back, extremities and head and neck. To the best of our knowledge, only 50 cases have been reported in adults in the English literature. A 42-year-old man presented with a polypoid skin nodule of the front side of the chest wall, measuring 1,8 × 1,5 cm. The lesion was removed completely with tumor-free margins. Microscopically, the tumor was composed of a diffuse infiltrate of polygonal cells, S 100 negatives, with abundant granular cytoplasm and vesicular nuclei. The diagnosis of dermal nonneural granular cell tumor was retained. No recurrence was noted during follow up of 6 months. The prognosis is good.
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