Klebsiella pneumoniae is not only one of the major pathogens acquired from hospital, but it is also one of the pathogens transmitted through urine samples that causes the liver Abscesses, blood poisoning, diarrhea. The study aimed to isolate the Hypervirulent Klebsiella pneumoniae (Hvkp) bacteria from clinical samples in Al-Diwaniyah city / Iraq. And evaluation of the efficiency of some antibiotics in inhibiting isolates. The study extended from January to mid-April. A total of 50 isolates identified as Klebsiella pneumonia using traditional biochemical tests, Of them, 13 isolates were hypervirulent, with a percentage of 26% of the studied isolates. A drug sensitivity test was conducted for 10 antibiotics and they were as follows (Amoxicillin – clavulanat, Cefotaxime, Ceftazidime, Ceftriaxone, Cefoxitin, Imipenem, Meropenem, Azteronam, Amikacin and Gentamicin) The ratio of resistance to an antibody Amoxicillin – clavulanat have reached 50% While the percentage of resistance to  Cefotaxime 46%  While the percentage of resistance to Ceftazidime 56% While the percentage of resistance Ceftriaxone 60%   While the percentage of resistance to Cefoxitin, Imipenem, Meropenem, Azteronam, Amikacin and Gentamicin Straight (56% , 20% ,26% , 40% , 46%, 56%).