Globally, the infection with Helicobacter pylori is considered the most prevalent issue that causes chronic inflammation of t stomach. In this study, the phytochemical investigation of Arengaengleri (family Arecaceae) leaves extract that used to prepare the AgNPs was performed and examined for their potential activity against H. pylori. The phytochemical results revealed the presence of different phenolic contents dep content and total flavonoid content measurements, and HPLC profiling. Besides, the percent of unsaturated and saturated fatty acids were 51.39 % and 31.47 %, respectively. The as spectroscopy, TEM, XRD, and Zeta potential. The synthesized AgNPs displayed promising anti H. pylori with MIC = 7.81 µg/mL, while the A. engleri extract showed weak activity with MIC = 500 µg/mL compa µg/mL after 3 days ofincubation. In conclusion, the organic acids, phenolic, and flavonoid contents of A. engleri extract wer used as capping agents to prepare simple, low their high penetration towards the bacterial cell of H. pylori and destroyed it.