In this study, we administered constant intravenous infusions of human islet amyloid polypeptide (hIAPP) to conscious dogs during euglycemic glucose-clamp studies. The doses of hIAPP used (5 and 50 pmol.kg-1.min-1) raised the circulating IAPP levels approximately 12- and 50-fold above basal levels, respectively. Studies were conducted at two different insulin infusion rates, resulting in steady-state plasma insulin levels of approximately 600 and 2800 pM. According to our results, the hIAPP infusions did not lead to any measurable change in the insulin-stimulated glucose disposal rate at either insulin infusion rate. Additionally, we observed no effect of IAPP on hepatic glucose production. Although we did not observe any effect of hIAPP on any of the aspects of glucose or insulin metabolism measured, we did find a consistent hypocalcemic effect of this peptide at the 50-pmol.kg-1.min-1 infusion rate. Shortly after the onset of hIAPP infusion, serum calcium levels fell by 10-15% and remained at these levels throughout the course of the hIAPP infusion. In summary, 1) infusion of hIAPP at doses of 5 or 50 pmol.kg-1.min-1 in conscious dogs raised the circulating IAPP level 12- to 50-fold above basal; 2) during these infusion studies, no effect of hIAPP was observed on any of the aspects of glucose or insulin homeostasis measured; 3) 50 pmol.kg-1.min-1 hIAPP lead to a prompt reduction in plasma calcium concentrations with intravenous administration.

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Kyllinga triceps rottb. A monocot perennial herb found in various parts of India is traditionally used in vitiated conditions pitta and vata, hyperdipsia, fever, liver disorders, verminosis, cough, splenopathy, diabetes and dermatitis. The aim of the present study was to evaluate the phytochemical and pharmacognostical study of ignored ayurvedic medicinal herb kyllinga triceps rottb. The plant is monocot grass belongs to the family cyperaceae, commonly used in various ayurvedic preparation’s and called musta. In various ayurvedic texts it is also known as nirvishi. Many species of family cyperaceae resembles the original drug thus the present study will help in identification and collection of original plant. The study includes identification and characterization of chemical component and preliminary phytochemical screening of the plant extract. The generated information of the present study will provide data which are helpful in the correct identification and authentication of medicinal plant kyllinga triceps rottb. and may help in prevention of its adulteration. Keywords: Kyllinga triceps rottb., phytochemical, cyperaceae, adulteration, ayurevedic.

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