Takayasu's arteritis should be kept under the differential diagnosis of stroke in all young patients. Early, proper diagnosis and treatment are necessary to reduce any further progression, morbidity, and mortality rates of the disease.
The emergency state caused by COVID-19 saw the use of immunomodulators despite the absence of robust research. To date, the results of relatively few randomized controlled trials have been published, and methodological approaches are riddled with bias and heterogeneity. Anti-SARS-CoV-2 antibodies, convalescent plasma and the JAK inhibitor baricitinib have gained Emergency Use Authorizations and tentative recommendations for their use in clinical practice alone or in combination with other therapies. Anti-SARS-CoV-2 antibodies are predominating the management of non-hospitalized patients, while the inpatient setting is seeing the use of convalescent plasma, baricitinib, tofacitinib, tocilizumab, sarilumab, and corticosteroids, as applicable. Available clinical data also suggest the potential clinical benefit of the early administration of blood-derived products (e.g. convalescent plasma, non-SARS-CoV-2-specific immunoglobins) and the blockade of factors implicated in the hyperinflammatory state of severe COVID-19 (Interleukin 1 and 6; Janus Kinase). Immune therapies seem to have a protective effect and using immunomodulators alone or in combination with viral replication inhibitors and other treatment modalities might prevent progression into severe COVID-19 disease, cytokine storm and death. Future trials should address existing gaps and reshape the landscape of COVID-19 management.
The study aimed at identifying the nature of the attitudes of Jordan elites regarding the coverage of news websites regarding current political events and revealed their motives to view/follow these websites. Moreover, the study was interested to know the major current political events which deserve to be viewed /followed by the population of the study. To achieve the objectives of the study, the researchers embarked upon the nature of descriptive studies, within the framework of which, the survey method was used by applying the method of surveying the population by sample. The questionnaire was distributed to (200) Jordan elites representing Academic and Media professionals, who were randomly selected. The study concluded the following major findings: 1. (46.5%) of the population of the study largely view/follow the current political events on electronic news websites. 2. The findings confirmed that the events of Deal of the Century and its repercussions occupied the first grade by (12.9%) followed by the Iraqi crisis, which occupied the second grade by (10.5%). 3. (42.6%) of Jordan elites prefer to view/follow the current political events via foreign Arabic-speaking electronic news websites. 4. The confidence demonstrated by Jordan elites about the effectiveness of coverage of news websites to current political events was medium. 5. The phrase “The coverage of news websites to current political events that cleared my ambiguity and misconception concerning some issues” occupied the first grade on the list of attitudes of Jordan elites regarding the coverage of news websites to current political events.
: The Kuwait Association of Rheumatology members met three times in April 2020 to quickly address and support the local practitioners treating rheumatic disease in Kuwait and the Gulf region during the COVID-19 pandemic. As patients with rheumatic and musculoskeletal disease (RMD) may need modifications to their therapy during the COVID-19 pandemic, we voted online for general guidance that local practitioners needed. In this review, we have addressed the vulnerability of rheumatic patients and issues surrounding their optimum management. We base our recommendations on a synthesis of national/international guidelines and expert consensus among KAR members in the context of the Kuwaiti healthcare system caring for the patient population with RMD. The most recent reports from the World Health Organization, the Center for Disease Control, the National Institutes of Health – National Medical Library, and the COVID-19 educational website of the United Kingdom National Health Service have been incorporated. We discuss the management of RMD in various clinical scenarios: screening protocols in an infusion clinic, medication protocols for stable patients and care for suspected or confirmed COVID infection and whether they are stable, in a disease flare or newly diagnosed. Besides, we also outline the conditions for the hospital admission. This guidance is for the specialist and non-specialist readership and should be regarded as interim as the virus is relatively new and we rely on experience and necessity more than evidence collection. The guidance presented should be supplemented with recent scientific evidence wherever applicable.
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