No abstract

An efficient synthesis of 3-trifluoromethyl-1-(3,4-difluorophenyl)-1H-pyrazol-5(4H)-one (3) and their Knoevenagel condensation reaction with 1,4-diphenyl -1H-pyrazole-3-carbaldehydes 4, 4-oxo-4H-chromene-3-carbaldehydes 6 and 2-chloroquinoline-3-carbaldehydes 8 have been described by using conventional and non-conventional techniques. Comparison of conventional and non-conventional techniques like Microwave , Ultrasonic assisted reactions showed that, the later procedure require shorter reaction time, good yield and was applicable for larger set of substrates emphasizing the importance of eco-friendly conditions.

Enantioselective syntheses of nonracemic secondary alcohols have been achieved in an aqueous micellar medium via copper-catalyzed (Cu­(OAc)2·H2O/(R)-3,4,5-MeO-MeO-BIPHEP) reduction of aryl/heteroaryl ketones. This methodology serves as a green protocol to access enantio-enriched alcohols under mild conditions (0–22 °C) using a base metal catalyst, together with an inexpensive, innocuous, and convenient stoichiometric hydride source (PMHS). The secondary alcohol products are formed in good to excellent yields with ee values greater than 90%.

No abstract

An environmentally benign, scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst. The methodology is also applicable to the regioselective synthesis of N-aralkyl/alkyl 2-pyridones.