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Data from this open-label study suggest that infliximab is a rapidly effective treatment for patients with severe, treatment-resistant disease, although approximately 25% of patients had to discontinue therapy due to the development of serious adverse effects. Long-term follow-up, continued pharmacovigilance, and further controlled comparative studies will be required to evaluate fully the risks associated with infliximab in the context of this already difficult to treat population.

This review of the literature on palmoplantar hypokeratosis, a process that was first indentified only 10 years ago, discusses the current state of our understanding, the therapeutic options available, and the debate about etiology. Forty-four publications reporting 69 cases were found. Palmar or plantar hypokeratosis occurs mainly in women (76.8%) and age at the time of a first visit to a physician ranges from 42 to 84 years. Most cases present between the ages of 51 and 70 years. The majority of patients have had solitary lesions usually located on the right palm, particularly in the regions of the thenar (in 44/79 lesions [55.7%]) or hypothenar eminences (in 11/79 lesions [13.9%]). In only 8 cases was there a history of prior trauma at the site. Studies using polymerase chain reaction techniques to identify human papillomavirus involvement were negative in most cases. These hypokeratotic lesions are localized epidermal depressions formed by an abrupt thinning of the stratum corneum, providing a singular histopathologic feature. This condition can currently be considered a localized keratinization disorder affecting zones where there is a thick stratum corneum. The precipitating cause is unknown and a definitive treatment remains to be found. The mechanism would be the localized failure of a clone of keratinocytes during differentiation toward normal palmoplantar hyperkeratinization. Palmas y plantas; Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripciónResumen Se revisa el estado actual de un nuevo proceso y los avances que han ido apareciendo en la literatura respecto a su estudio, posibilidades terapéuticas y controvertida etiología, tras ଝ Please cite this article as: Urbina F, Pérez A, Requena L, Rütten A. Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripción. Actas Dermosifiliogr. 2014;105:574---582.Palmar or Plantar Hypokeratosis 575 Palmoplantar; Queratinización; Queratinocito justo una década de su descripción inicial. Hemos encontrado 44 publicaciones al respecto, con 69 casos. Predomina en mujeres (76,8%), con edades entre los 42 y 84 años para toda la casuística en el momento de la consulta, siendo el rango más frecuente de aparición de las lesiones entre los 51 y 70 años. La gran mayoría de las veces fueron lesiones únicas y se localizaron predominantemente en la palma derecha, preferentemente en la región tenar, con 44/79 lesiones (55,7%) y luego en la hipotenar, con 11/79 lesiones (13,9%). Solo en 8 casos se obtuvo el antecedente de un traumatismo previo. Los estudios mediante PCR en búsqueda de papiloma virus humano han sido negativos la gran mayoría de las veces. Las lesiones consistieron en una depresión focalizada de la epidermis producida por una brusca disminución de espesor de la capa córnea, delimitando un singular concepto histolopatológico. En la actualidad puede ser considerada como un trastorno focalizado de la queratinización, que afecta zonas con un estrato córneo grueso, cuya c...

An 11-year-old girl with a history of insulin-dependent diabetes mellitus had erythema elevatum diutinum (EED) associated with a celiac disease related to a possible kidney disease. Dapsone did not improve the skin manifestations. However, the lesions disappeared after a gluten-free diet was begun. To our knowledge, this report describes the first case of EED in a patient with celiac disease.

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