Introduction: Radiotherapy still the most facilitated modality for treatment malignant brain tumors with or without chemotherapy and after surgery or when surgery is impossible. Purpose: Comparison between the effects of three planning techniques with similar, opposed and non-wedges in brain tumor cases. Methods: Twenty patients with brain tumors (Glioblastoma Multiform) of both sexes were enrolled in the study. A LINAC with 6MV photon beam was used to deliver the prescribed dose. The whole brain technique was applied to each patient and the planning was constructed with nonwedges, similar wedges and opposed wedges within 95% to 107% of the prescribed dose as recommended by the RTOG. The considered organs at risk were; Right and Left (eyes, lenses, and optic nerves), optic chiasma and the brain-stem. Results: The results showed significant difference (at the level P<0.05), between the three planning based on the conformity, homogeneity indexes, global max, and the doses received by the OARs. The results were discussed.