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Most of the nonsteroidal anti-inflammation drugs (NSAID) have some demerits depending on type and nature of physical conditions and limit of doses. Herein, we report the optimization of Naproxen and its degradants employing density functional theory (DFT) with B3LYP/6-31g+(d,p) level theory to elucidate their thermal and molecular orbital properties. Molecular docking and nonbonding interactions have been performed against prostaglandin synthase protein (5F19) to search binding affinity and interactions of all compounds with the respective protein. Pharmacokinetic properties also calculated to search their absorption, metabolism, and carcinogenicity.

Endometrial receptivity disorder is the leading cause for failed embryonic implantation. Recently, the methods to ameliorate endometrial receptivity, to improve the success rate and increase the clinical pregnancy rate of in vitro fertilization-embryo transfer (IVF-ET) technology has become a research hotspot. In this article, we describe the treatment methods and elaborate the latest progress made in improving endometrial receptivity in the recent years.

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