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There are many traditional medicines that can be used as alternative medicine. One of them is methanol extract ofmauli banana stems. Some people in North of Hulu Sungai Banjarmasin use it as healing agent. The aim of thisresearch was to test antibacterial activity of mauli banana stems extract against Streptococcus mutans; as well as todetermine the effective concentration of its antibacterial activity against S.mutans. The extraction was conducted bymaceration method. Viscous extracts were diluted by using 10% dimethyl sulfoxide and filtered with Whatman paperfilter. Those extracts were divided into four treatment groups: 6.25% (I), 12.5% (II), 25% (III), and control (-)(IV).Groups I, II, and III were added with Muller Hinton media to reach the concentrations. 100 μL S.mutans suspension of0.5 Mc Farland was administered to each concentration, incubated for 18 hours, diluted to 1/10 using NaCl. 100 μLwas taken and planted to blood agar media for 24 hours incubation. The numbers of S.mutans colonies were countedand statistically analysed by one-way anova test and post hoc LSD (p<0.05). The results showed that there weresignificant differences between each treatment, and extract concentration of 25% had better antibacterial activity thanthe others. It was concluded that extract of mauli banana steams have antibacterial activity against S.mutans, andmauli banana stem have the potential to be used as an alternative herbal mouthwash.

Toman fish contains albumin and omega-6 fatty acid that are instrumental in the healing process of diabetes mellitus (DM) wound. People with DM usually have a prolonged wound healing process. Albumin controls the osmotic pressure, the development of granulation tissue, gives the energy to re-epithelialisation process and collagen base material. Omega-6 fatty acid interrupts phagocytosis induced by neutrophil cells. It increases the action of machropage cell, so that Toman fish can be used as an alternative in accelerating the DM wound healing process. The purpose of this research is to prove the effect of Toman fish extract at 16 mL/ KgBW rat dosage per oral on wound length and contraction on the back of wistar rat (Rattus novergiucs) with DM for 14 days. It was the experimental with a posttest only with control group design  used 12 wistar rat that were divided into 3 groups; the group of Toman fish extract with dose 16 mL/ Kg BW rat, positive control group using Haruan extract with dose 13,54 mL/ Kg BW rat and negative control group using Comfeed BR2 feed. One-way ANOVA test result for wound length and contraction (p= 0,000). The result Post-hoc Least Significant Difference test for wound length and contraction shows that there are significant differences between the group of Toman fish extract and Haruan fish extract (p= 0,000). There is also significant difference between the group of Toman fish extract and Comfeed BR2 feed (p= 0,000). There is no significant difference between the group of Haruan fish extract and Comfeed BR2 feed (p= 0,930). The research concluded that Toman fish extract at 16 mL/ Kg BW rat dosage affects the length and contraction of diabetic mellitus wound. Keywords: Channa micropeltes, clinical analysis, diabetes mellitus, wound

Introduction: Recurrent aphthous stomatitis (SAR) is a recurrent ulceration lesion where many Streptococcus sanguis bacteria are found. Streptococcus sanguis bacteria can be killed by compounds that contain antibacterial. Kapul fruit (Baccaurea macrocarpa) is a typical Kalimantan fruit, has antioxidant and antibacterial activity which serves to kill Streptococcus sanguis. Method: Performed a quantitative phytochemical test on the kapul fruit peel and continued with the antibacterial activity test using the disc diffusion method of kapul fruit peel extract at the concentrations 20%, 40%, 60%, 80%, 100%,Chlorhexidine as a positive control and aquades as a negative (n=4/group). Result: From the phytochemical test, Kapul fruit peel extracts contain 35,851% of alkaloid, 23,225% of saponin, 2,395mg of tannin and 21,000mg of flavonoids. Kapul fruit peel extracts has the potential as an antibacterial against Streptococcus sanguis at concentration of 40%, 60%, 80% and 100%. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential. Conclusion:The potential of Kapul peel Extract as antibacterial to Streptococcus sanguis bacteria on 40%, 60%, 80%, 100% concentration. The concentration at 100% has an equivalent to chlorhexidine as an antibacterial potential.

Oral administration of Toman fish extract is proven to accelerate wound healing in rat model of Diabetes Mellitus. Toman fish extract contains albumin which may elevate antioxidant level and reduce inflammation. These changes will later enhance cell proliferation and inflammatory cell activity in wound healing process. This study was aimed to determine the topical application effect of 20% toman fish extract on macrophages and lymphocytes in Diabetes Mellitus wound healing. It was an experimental research using post-test only with control group design. This study was performed on 36 diabetic male wistar rats which was comprised of negative control group without given any treatment, 20% Toman fish extract ointment group and 10% Haruan fish (Channa striata) extract ointment group. Rats were sacrificed on day 4, 8, and 14 to investigate wounded area with biopsy technique which later obtained histological preparation using Haematoxylin-Eosin staining. The preparation was then observed using microscope to count macrophages and lymphocytes number. One-Way ANOVA test demonstrated a significant difference in macrophage number on day 4 (p=0.002), day 8 (p=0.000), day 14 (p=0.000). The result of the test also indicated a significant difference in lymphocyte number on day 4 (p=0.001), day 8 (p=0.001), and day 14 (p=0.001). Furthermore, Post Hoc LSD test resulted in a significant difference (p<0.05) of macrophage and lymphocyte in day four, eight, and fourteen among all treatment groups. Toman fish extract ointment at 20% concentration for topical application may raise the number of macrophage and lymphocyte than those of negative control and 10% haruan fish extract ointment on day 4 and 8 with gradual decrease on day 14.