Background Checkpoint inhibitors have revolutionized advanced melanoma care; however, their cutaneous side effects have not been definitively elucidated. Objective To identify the prevalence of cutaneous toxicity in patients with melanoma treated with immune checkpoint inhibitors as monotherapy and/or in combination with chemotherapy and/or radiotherapy. Materials and methods We performed a systematic review and meta-analysis, which encompassed both clinical trials and observational studies describing the dermatological toxicities in patients treated with immune checkpoint inhibitors. The protocol was registered in the International Prospective Register of Systematic Review under the number CRD42018091915. The searches were performed using the CINAHL, Cochrane CENTRAL, LILACS, LIVIVO, PubMed, Scopus, and Web of Science databases. The methodological quality of the studies was evaluated with the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data Results A total of 9,802 articles were identified in the databases. The final sample comprised 39 studies. The evaluated drugs were ipilimumab, tremelimumab, pembrolizumab, and nivolumab. The results suggest that the most prevalent side effect was grade 1 and 2 pruritus (24%), followed by grade 1 and 2 rash (21%) and grade 1 and 2 vitiligo (10%). Conclusion The most prevalent side effects in patients treated with checkpoint inhibitors are pruritus, rash, and vitiligo, and they are rated mostly as grades 1 and 2 adverse events. Remarkably, vitiligo is most commonly found in patients treated with PD-1 inhibitors.

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Objetivo: Identificar as principais intercorrências e o desfecho clínico de idosos internados por causas traumáticas na Unidade de Terapia Intensiva de um hospital de referência do Distrito Federal admitidos entre julho de 2012 e julho de 2014. Método: Estudo retrospectivo analítico, com coleta de dados em prontuário. Os dados foram analisados com os testes Qui-Quadrado e Mann-Whitney, considerando como significativo um valor de p<0,05. Resultados: Dentre 91 idosos, houve prevalência do sexo masculino e da queda da própria estatura, como mecanismo de lesão. As principais intercorrências foram: infecção pulmonar, traqueostomia decorrente de intubação prolongada e choque séptico. Observou-se alta mortalidade, 38 (41,7%), associada ao sexo masculino (p=0,029), às outras causas externas (p=0,03), ao choque séptico (p=0,039) e à diálise (p=0,015). Conclusão: A maior gravidade apresentada favoreceu a ocorrência de múltiplas intercorrências durante a internação na terapia intensiva; entretanto, apesar do pior prognóstico, os idosos podem sobreviver ao trauma e suas complicações associadas. DESCRITORES: Idoso; Causas externas; Ferimentos e lesões; Mortalidade; Unidade de terapia intensiva.Objective: To identify the main complications and the clinical outcome of elderly trauma victims admitted to the Intensive Care Unit of a referral hospital of Distrito Federal between July 2012 and July2014. Method: Retrospective analytical study that uses medical records. Data were analyzed using Chi-Square and Mann-Whitney tests, and a significance value of p <0.05 was considered. Results: Most of the 91 elderly were men, whose mechanism of injury was falls from standing height. The main complications were pulmonary infection, tracheostomy due to prolonged intubation and septic shock. There was a high mortality rate: 38 (41.7%), associated with male gender (p = 0.029), other external causes (p = 0.03), septic shock (p = 0.039) and dialysis (p = 0.015). Conclusion: The severe condition of the patients favored the occurrence of multiple complications during hospitalization in intensive care. However, despite the worst prognosis, the elderly may survive the trauma and its associated complications.Objetivo: Identificar las principales complicaciones y su resultado clínico asociadas a ancianos ingresados a causa de traumas en la Unidad de Terapia Intensiva de un hospital de referencia de Distrito Federal entre julio de 2012 y julio de 2014. Método: Estudio retrospectivo analítico, con obtención de datos en prontuario. Se analizaron los datos por medios de los test Chi cuadrado y Mann-Whitney, considerando como significativo un valor de p<0,05. Resultados: De 91 ancianos, hubo prevalencia del sexo masculino y de la caída de la propia estatura, como mecanismo de lesión. Las principales complicaciones fueron infección pulmonar, traqueostomía proveniente de intubación prolongada y choque séptico. Se observó gran mortalidad, 38 (41,7%), asociada al sexo masculino (p=0,029), a otras causas externas (p=0,03), al choque séptico (p=0,039) y a la di...