Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled "Sm13-16,23"), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.
En este artículo se describe el caso de una Suricata suricatta de 5 años, hembra, nacida bajo cuidado humano en el Zoológico de Cali, Colombia, que presentó reporte de comportamiento anormal. Al examen clínico se observó alopecia multifocal y simétrica bilateral con costras. Se realizó una evaluación ultrasonográfica que determinó la presencia de quistes ováricos. Como alternativa terapéutica se realizó una ovariohisterctomía (OVH) con biopsia escisional de ambos ovarios, que fueron remitidos al laboratorio de patología. Los hallazgos histopatológicos concluyeron una neoplasia del ovario izquierdo consistente con un Luteoma. El ovario derecho no presentó lesiones significativas. Durante la cirugía se tomaron muestras de sangre que indicaron que el paciente presentaba anemia regenerativa, química sanguínea con aumento del BUN y proteínas totales asociados a una hiperglobulinemia indicativos de un proceso inflamatorio crónico. La paciente se recuperó satisfactoriamente de la cirugía y tras dos semanas posteriores al procedimiento, las lesiones dermatológicas remitieron, así como los problemas de comportamiento previamente reportados.
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