Introduction: Metabolic acidosis is associated with the high mortality seen in hemodialysis patients. The panorama of metabolic acidosis in hemodialysis in Brazil is unclear since 1996 when the analysis of bicarbonate levels was no longer a compulsory exam. We aimed to establish the prevalence of metabolic acidosis in a hemodialysis population and analyze the factors associated with low bicarbonate levels. Methods: A cross-sectional study was carried out to assess the prevalence of metabolic acidosis in adults undergoing regular hemodialysis from January to April 2017, in four dialysis centers from Niteroi, Rio de Janeiro, Brazil, and surroundings. For blood gas analysis, samples of 2 mL were collected in heparinized syringes before a midweek dialysis session. Results: 384 patients with a mean age of 58.1 ± 15.8 years (54.5% men and 63.0%, non-white) were included. Approximately 30% had diabetes and 48%, hypertension. Nearly 88% used primary arteriovenous fistula as vascular access. The pre-dialysis mean serum tCO2 in the midweek session was 22.7 ± 3.0 mEq/L. The prevalence rate of serum bicarbonate below DOQI recommendation (22 mEq/L or higher) was 40.3%, and 6.5% had serum bicarbonate < 18 mEq/L. The dialyzer use count and the use of low-flux dialyzers were negatively associated whereas age and the standard Kt/V values were positively associated with the serum bicarbonate levels. Conclusion: The findings were in agreement with global data reported in previous studies. However, because the sample was relatively small and non-representative of the Brazilian population, a more comprehensive study, addressing national data is necessary to substantiate our findings.
O objetivo do presente estudo foi investigar na literatura a ação do resveratrol como um antiaterogênico bem como seu efeito sobre a pressão arterial. Foram utilizados artigos publicados em três bases de dados científicas: Pubmed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) e Scientific Electronic Library Online (SciELO), sendo adotados como critérios de elegibilidade estudos observacionais de coorte, caso-controle e transversais referentes a temática, publicados entre os anos de 2015 e 2020, nos idiomas inglês e português. O resveratrol apresentou efeitos positivos no tratamento e prevenção da aterosclerose e no controle da pressão arterial, no entanto, embora os estudos apresentados tenham se mostrado satisfatórios quanto a ação do RSV sobre a redução do risco de aterosclerose e uma diminuição significativa dos níveis de PA, é válido ressaltar que a maioria das pesquisas foram realizadas em camundongos, o que o implica em uma incerteza a respeito de seus efeitos sobre a população humana. A administração de resveratrol se mostrou altamente benéfica à saúde cardiovascular, sobretudo na melhora da função endotelial, perfil lipídico e diminuição do estresse oxidativo, o que culminou em um poderoso aliado no combate e prevenção da aterosclerose e na redução dos níveis de pressão arterial.
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