We present the results of a global fit to the Aligned Two-Higgs Doublet Model, assuming that there are no new sources of CP violation beyond the quark mixing matrix. We use the most constraining flavour observables, electroweak precision measurements and the available data on Higgs signal strengths and collider searches for heavy scalars, together with the theoretical requirements of perturbativity and positivity of the scalar potential. The combination of all these constraints restricts the values of the scalar masses, the couplings of the scalar potential and the flavour-alignment parameters. The numerical fits have been performed using the open-source HEPfit package.