Biofeedback is a noninvasive method of measurement of physiological functions where precise instruments measure the slightest changes in body functions. Many of the studies have shown that using biofeedback can reduce the occurrence of migraine or reduce the strength of the pain. Some results from a study suggest that the use of biofeedback in combination with medication is more successful than medication alone in treating migraines. Also, holistic approach by using behavioral technic is necessary to provide maximal results by methods. To more precisely work with patients who suffer from a migraine, it is also important to know the pathophysiology of a migraine. According to relevant research, we combined biofeedback treatment that consisted of a combination of three forms of biofeedback treatment: neurofeedback, breathing, and vascular biofeedback. Combination of treatments in 25 sessions helped the patient with a long history of a severe migraine. Further research of patients suffering from a migraine with different treatment protocols is needed to establish the method.