The study assessed the impact of effluent discharges on the quality of Otamiri River in Imo state, Nigeria. Six water samples were collected at discharge points where the industries discharge their effluents and abattoir. Samples that were collected upstream and downstream were analyzed in the field and in the lab using standard procedures.  The source of pollution is attributable to industrial and abattoir activities whose effluent discharges impact the quality of Otamiri River. Therefore, without any treatments, the River cannot be used for any residential purposes in its current condition. It is advised that the river be periodically monitored and that cost-effective manufacturing technology, such as on-site waste separation and reduction, effluent recycling techniques, be introduced.