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Megalencephalic leukoencephalopathy (MLC) with subcortical cysts is a very rare white matter disorder characterized predominantly by motor developmental delay and seizures in a child with macrocephaly. Extrapyramidal symptoms, ataxia and mental retardation may also occur. Only a few cases of the disease have been reported worldwide with most of them showing an autosomal recessive pattern of inheritance. In India, most cases have been reported in Agrawal community. Here, we present an interesting case of MLC in a child born in non-Agrawal community to a non-consanguineous marriage. By reporting this case we intend to increase the research horizon and increase the published literature for atypical cases of MLC.

The purpose of the study was to determine the effect of integrated physical activity training on social phobia. In this experimental research study, the subjects were 51 girls (age 13 to 16 years) of children's homes of Greater Mumbai. The design of the study was Non-equivalent Control Group Design. The dependent variable was social phobia and the psychological test administered was Social Phobia Scale (SPS). The independent variable (treatment) was Integrated Physical Activity Training for the period of 8 weeks, 5 days a week and 60 minutes morning session which comprised of yoga, physical exercise and team games. The comparison of data (pre test -post test) of control group and experimental group was analyzed with the help of one way analysis of covariance Ancova. The result added new information that the level of social phobia has been reduced due to the treatment of Integrated Physical Activity Training among the adolescent girls of children's home.