Necrotizing sialometaplasia can make anyone very anxious about the lesion especially if they have habit of tobacco consumption. It requires a prompt diagnosis, counseling with assurance to patient and treatment.

Necrotizing sialometaplasia is a salivary gland disease which is clinically as well as histologically quite confusing with a malignant squamous cell carcinoma. Presenting here a case of a male with Necrotizing sialometaplasia who was anxious because of cancerphobia as he was a smoker.

In midst of the recent dengue outbreak in Nepal, in 2022, the risk of co-infection increases and may lead to fatal outcomes if the diagnosis of multiple infections is delayed. Thus, all available diagnostic approaches must be taken to decrease the burden of illness and lessen mortality.

Introduction: Looking at the health status of our country Nepal, iron deficiency anemia fits rightly in our socioeconomic status and dyslipidemia is the rising one along with being more highlighted these days. Some studies show an association between iron deficiency anemia and dyslipidemia but the data are controversial. Therefore, this study is aimed to find the relationship between iron deficiency anemia and serum lipid profile in the Nepalese context.Materials and Methods: A cross-sectional study was conducted in KIST Medical College and Teaching Hospital from June 2019 to August 2020. 76 Iron deficiency anemia and 75 age and sex-matched healthy control were investigated for any possible changes in serum lipid profile: triglyceride, low-density lipoprotein, high-density lipoprotein, and total cholesterol.Results: The mean triglyceride in case and control was 92.96 mg/dl and 99.87 mg/dl respectively. The difference between these two groups was statistically significant (p=<0.001). Moreover, serum total cholesterol level in the case (138.82 mg/dl) was significantly lower than the control (146.67 mg/dl). The mean high-density lipoprotein was almost the same in anemic and non-anemic groups, p=<0.001. While the mean low-density lipoprotein in theiron-deficiency anemia group was significantly lower than the control group (p=<0.001).Conclusions: In this study, the values of the lipid profile parameters: triglyceride, low-density lipoprotein, high-density lipoprotein, and total cholesterol in cases were found to be lower than those in the controls.

Background: Venereal syphilis is a sexually transmitted disease, involving pathological activities mediating tissue destruction by extensive tissue necrosis. As such, the goal amongst researchers has been set to the identification of effective laboratory biomarkers that can reflect the broad spectrum of disease and ultimately aid in timely diagnosis and effective treatment of syphilis. This research aimed to study the applications of hematological biomarkers associated with syphilitic patients visiting a tertiary care hospital. Methods: A retrospective cross-sectional study was conducted in the syphilitic patients attending KIST Medical College and Teaching Hospital, Lalitpur, Nepal. A total of 25 syphilitic patients and 41 non-syphilitic participants were included. The rapid plasma reagin test and Treponema pallidum hemagglutination assay were used for the screening and confirmation of syphilis respectively. The hematological investigation was performed using a hematology analyzer. Statistical Package for Social Science version 17.0 was used for data analysis. A P value <0.05 was considered significant.Results: Syphilitic patients showed significantly elevated levels of lymphocytes (39.8±11.5) (p=0.025), monocyte (1.9±0.8) (p=0.002), mean corpuscular volume (MCV) (92.6±12.9) (p=0.005), and mean corpuscular hemoglobin (MCH) (31.9±4.6) (p=0.008) and lowered levels of red blood cell (RBC) (4.2±0.3) (p=0.005) and platelets (237.2±628.6) (p=0.048) as compared to the lymphocytes (32.9±11.9), monocyte (0.6±1.2), MCV (83.9±8.8), MCH (34.3±1.5), RBC (4.6±0.7), and platelets (280.9±113.3) of the non-syphilitic participants. Conclusions: The results showed that the elevated levels of lymphocyte, monocyte, MCV, and MCH and lowered levels of RBC and platelets are highly specific hematological biomarkers for the diagnosis of patients with syphilis.Keywords: Hematological biomarkers; sexually transmitted disease; syphilis