No abstract

The aim of the work was the study of the biological activity of technologically available flavonoid isolated from Salsola collina Pall. and Serratula coronata L. plants growing on the territory of Kazakhstan, as well as some modified derivatives of flavonoid quercetin and crude extracts. The method of acute hypoxia was applied in experiment to determine antioxidant activity of modified flavonoid and plant extracts. The results of in vivo bio screening on antioxidant activity have shown that quercetin and dry extracts of Serratula coronata L., as well as the extracts of Salsola Collina Pall. show remarkable antioxidant activity. It was found that the concentration of malondialdehyde in the brain and liver tissues of laboratory rats, which were preventively treated with flavonoids and extracts, is lower than in the control animals and is close to that of the intact group. Quantitative comparison showed that antioxidant effect is more significant in the case of extract of Serratula coronata L. Explanation of the high antioxidant effect in the studied plant of Serratula species lies in the composition of the extract. Feature of the whole extract of Serratula coronata L is the presence of molecules with a diphenyl structure, which opens up the possibility of participation in the reconstruction of biomembranes, lipid‐sensitive processes.

The most important of flavanoids in metabolism in vegetable cell is connected with its ability to make up tough chelate complexes with various ions of metals. Also the ability to interact with free radicals, to participate in electrons’ transport, to connect with various enzymes, changing their activity. Flavanoids are able to penetrate into cell membranes where the flavanoids destroy the primary and by‐productive of lipids peroxidation (PLP). As we know pathological state in human’s body in that or another degree is closely connected with the processes PLP. We have made research of the comparative study of individual compounds of routine, quercertin’s influence and total medicines on the basis of hawthorn blood‐red, Russian thistle and saw‐wort upon the dynamics of lipids peroxidation under strict gycopsy at laboratory rats. About the PLP’s condition we have judged by the maintenance of malonic dialdehyde (MDA). Antioxidant activity we have valued by changing catalase activity in serum blood but antioxidant effect by inhibition peroxidation of liposomes at presence exogenous substances. It should be in mind that changes of catalase activity adequate antioxidant effect of having researched medicines. More marked antioxidant activity was expressive quercetin which can be explained by two factors: by the same doze of medicines, the less molar mass quercetin rises the concentration of substances.