Postpartum reproductive disorders cause heavy economic losses in dairy sector. Uterine infections include endometritis, metritis, mucometra, and pyometra. Postpartum endometritis in dairy cows has been defined as inflammation of endometrium occurring 21 days or more after parturition without systemic signs of illness. The treatment of endometritis with antimicrobials has met with varying degrees of success, inconsistent recovery rate, high cost of treatment, milk disposal, emergence of microbial resistance, and reduced phagocytic activity of polymorphonuclear leukocytes In our country, around 20,000 medicinal plant species have been recorded, but more than 500 traditional communities use about 800 plant species for curing different diseases. Many herbs such as garlic, neem, ashwagandha, and turmeric have been tried for the treatment of endometritis in cows with a good success.

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The study was carried out at the Veterinary Clinical Complex, College of Veterinary Science and Animal Husbandry, Mhow and in private clinics across Indore on 30 bitches suffering from Cystic Endometrial Hyperplasia-Pyometra Complex (CEH-PC). The animals were randomly subdivided into five groups each of six bitches and treated with bromocriptine (1 g/kg POx5 days) and cabergoline (5 g/kg POx5 days) alone and in combination with cloprostenol (5 g/kg s/c on day 0, 2 and 6) (Gr II to V) together with enrofloxacin (10-20 mg/kg PO, SID×5 days) + combination of metronidazole and povidone-iodine IU (5-10 ml×3 days), the later served as routine control Gr I.The treatment response of animals was evaluated through clinical, ultrasonographical, haematological and biochemical parameters. Blood samples were collected from cephalic or saphenous vein just before treatment (day 0) and after treatment on day 6 and day 14. Treatment approach -III (cabergoline 5 g/kg POx5 days) was found to be the most effective without side effects with significant decrease in uterine luminal diameter after treatment. The results showed significant improvement in haemato-biochemical attributes in dogs affected with CEH-P complex following treatment IV and V, i.e. with use of bromocriptine and cabergoline in combination with cloprostenol as compared to other groups.

The study was undertaken to evaluate the therapeutic efficacy of Neem (Azadiracta indica) extract in 20 infectious repeat breeder crossbred cows. Animals were divided into two groups of ten in each. The animals in first group were treated with 15% concentration of Neem extract w/v dissolved in saline to make 30 ml, Intra Uterine at 24 hrs intervals for 7 days, while the animals in control group were infused with 30 ml saline for 7 days. Bacterial count in uterine flushing declined significantly (p less than 0.05) after treatment in Neem group. A significant increase (p less than 0.05) in total cellular count and PMNs % was found in Neem group than in control group. An overall recovery rate of 80% vs 20% and conception rate of 50% vs 10% was found in Neem treated cows over control group proving its efficacy in infectious repeat breeder cows.

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