We have developed a novel method for the large-scale manufacturing of peptides in solution called DioRaSSP. It combines the advantages of the homogeneous character of classical solution-phase synthesis with the generic character and the amenability to automation inherent to the solid-phase approach. DioRaSSP is characterized by the fact that intermediates are not isolated. Processes according to this highly efficient synthesis method are easy to scale-up and yield products of reproducible high purity. Moreover, we have recently implemented the first fully automated solution-phase peptide synthesizer for application in processes according to DioRaSSP.