Radiofrequency encoded combinatorial (REC) chemistry is a recently
developed nonchemical
encoding strategy in library synthesis. Encoded chemical libraries
of complex molecular structures
like Taxol can be constructed employing the noninvasive REC strategy
and novel solid phase
synthesis techniques, as demonstrated by the synthesis of the first
400-membered taxoid library
in a discrete format and in quantities of
multimilligrams/member.
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