Parkia speciosa (Fabaceae),  much grow in South Sumatera. The seed of P. speciosa used as traditional medicine for  diabetes mellitus therapy. Another parts of P speciosa is suspected to have the same chemical compounds and potency as the seed. Based on phytochemical screening of leaf and rind of P speciosa have secondary metabolites as flavonoid, phenolic and terpenoid.  This research aims to know effectiveness of alpha glucosidase inhibitory effect of ethanol extract of rind, leaf and  seed of  p. speciosa and its correlation to total phenolic content of the extracts. The inhibitory activity of the alpha glucosidase enzyme was measured at l 405 nm. The result showed that there was correlation between effectiveness of inhibitory  and total phenolic content of the extract, that is the higher of  the total phenolic content will caused the greater of enzymatic inhibition of extract. The  IC50 of alpha glucosidase inhibitory effect of ethanol extract of rind, leaf and seed of P speciosa are 4,596 ppm, 54,341 ppm, dan 67,425 ppm and the total Phenolic content of the extract are 138,15 mgGAE/g, 59,25 mgGAE/g, dan 36,25 mgGAE/g respectively.

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The combination of tea leaf dregs extract and rice washing water as a peel-off gel mask was found to be stable up to 28 days of storage and had an IC50 value 20.4 ppm. This potential can provide an optimal effects as cosmetic ingredients.However, to meet the regulatory requirements of Badan Pengawas Obat Makanan (BPOM) RI and ISO 10993, a dermal sensitization test also need to be done. The aim of this study was to determine the dermal sensitization reaction from peel-off gel mask containing a combination of tea leaf dregsextract (Camellia sinensis L.) and rice washing water (Oryza sativa L.) in test animal. Thisstudy was designed based on experimental laboratory methods and sample selection by simple random sampling. The intervention was given based on posttest-only control group design. The test results for dermal sensitization were determined using the Guinea Pig Maximization Test (GPMT) method. The results showed erythema and edema reactions according to the Magnusson and Kligman scale after administration of peel-off gel masks as samples in the topical tests in test animals, appeared on the 11th day and in the challenge test appeared on the 24th day. This was due to incubation period for one week where the hypersensitivity state can develop, so that this reaction is also called the delayed hypersensitivity reaction