The objective of this work is to elaborate good practice guidance, aimed at preparing and administering drugs through feeding tube. This study was performed at a secondary level hospital in the interior of São Paulo state, Southeast Region of Brazil. For the first phase, a literature review was carried out in the following databases: LILACS, MEDLINE, Web of Science, and MICROMEDEX® Solutions. A manual search was also carried on other sources. In a second phase, the guide was refined for the hospital through meetings. Out of 104 references found, seven were read in full. The most employed technique for drug preparation was a simultaneous crushing of solid formulations. Participants identified a need to standardize techniques for drug preparation and administration through feeding tube, and the importance of using best practice guidance for patient safety was acknowledged.