Seven flavonol 3- O-glycosides were isolated from the flowers of CALENDULA OFFICINALIS L. Their structures were elucidated as isorhamnetin 3- O-glucoside, rutinoside, neohesperidoside, 2 (G)-rhamnosylrutinoside, quercetin glucoside, neohesperidoside, and 2 (G)-rhamnosylrutinoside by paper and thin layer chromatography, UV, (13)C-NMR, and mass spectroscopy. The interglycosidic linkages of isorhamnetin 3- O-neohesperidoside, 2 (G)-rhamnosylrutinoside, quercetin 3- O-neohesperidoside and structural determination of quercetin 2 (G)-rhamnosylrutinoside are described for the first time in CALENDULA OFFICINALIS.

From the leaves of Hederá helix four new triterpenoid saponins, hederasaponins E [11, F [2], H [7], and I [81, and one known saponin (cauloside F) were isolated and characterized by chemical and spectroscopic methods.Saponins from the leaves of Hederá helix L. (Araliaceae) have antifungal, anthelmintic, molluscicidal, antileishmanial, and antimutagenic activities (1-5). Major saponins related to hederagenin and oleanolic acid have been found (6)(7)(8).As a part of our investigations of H. helix, we have previously reported the isolation and identification of hederasaponins B [6], C [4], and D (saponin K 10) [5] (9).

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