Herein a review on the methods for the formation and reaction of acyl hydrazides will be given. There is particular focus on the synthesis of acyl hydrazides from aldehyde precursors with examination of the various approaches (e.g. metal-based (rhodium, copper) and non-metal-based (aerobically- and photoorganocatalytically-initiated)) that have been used to achieve this. Finally, strategies to utilise acyl hydrazides for the formation of an array of useful entities will be detailed.

An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors.

Bis-thioaryl pyridazinediones are shown to be stable to blood thiols and cleave under intracellular conditions for self-immolative release of cargo.

Significant advancements in C−N bond formation via C−H bond functionalisation have made it a staple in the production of nitrogen-containing compounds in both industry and academia. However, transition metal-free synthesis,...