Industry 4.0 has revolutionized process innovation while facilitating and encouraging many new possibilities. The objective of Industry 4.0 is the radical enhancement of productivity, a goal that presupposes the integration of Operational Technology (OT) networks with Information Technology (IT) networks, which were hitherto isolated. This disruptive approach is enabled by adopting several emerging technologies in Enterprise processes. In this manuscript, we discuss what we believe to be one of the main challenges preventing the full employment of Industry 4.0, namely, the integration of Operation Technology networking and Information Technology networking. We discuss the technical challenges alongside the potential tools while providing a state-of-the-art use case scenario. We showcase a possible solution based on the Asset Administration Shell approach, referring to the use case of camera synchronization for collaborative tasks.