Notation c liquid phase solute concentration (g/l) c* liquid concentration in equilibrium (g/l) D z axial dispersion coefficient (cm 2 /min) D m solute dispersion coefficient in the axial direction (cm 2 /min) D h solute dispersion coefficient in the angular direction (cm 2 /min) k 0 a global mass transfer parameter (s -1 ) k¢ A normalized retention of compound A k¢ B normalized retention of compound B K distribution coefficient K m mass transfer coefficient between the mobile and the stationary phases K eq equilibrium partition coefficient m p amount of pure protein (mg) n cycle factor N eff effective plate number N th number of theoretical plates P productivity (mg/(ml min)) q solid phase solute concentration (g/l) q* solid concentration in equilibrium (g/l) Q F feed flow rate (ml/min) Q E eluent flow rate (ml/min) Q T total flow rate (ml/min) Q quantity Q R recovery ratio R resolution S particle area per unit column volume (cm 2 /ml) t retention time (min) t max reduced retention time (min) t t max retention time of dextran blue (min) t F feed time (min) t c cycle time (min) t c,1 time for the first cycle of batch column (min) t c,b time for n cycles of batch column (min) t¢ c,1 time for the first cycle of P-CAC (min) t¢ c,c time for n cycles of P-CAC (min) u superficial velocity (cm/min) V B buffer consumption V t column volume (ml) V E elution volume (ml)

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