We found a reduction in all-cause mortality after rectal but not colon cancer in patients having EDA compared with PCA technique.

The concentration of propofol in and surrounding the human brain during propofol anaesthesia is unknown. We measured simultaneously the concentration of propofol in cerebrospinal fluid (CSF) from an indwelling intraventricular catheter and the concentration in arterial blood in five neurosurgical patients before, during induction (at 2.5 and 5 min) and during a maintenance propofol infusion (at 15 and 30 min). After induction of anaesthesia with propofol 2 mg kg-1, anaesthesia was maintained with an infusion of 8 mg kg-1 h-1 for 15 min and then reduced to 6 mg kg-1 h-1. The plasma concentration of propofol increased rapidly during induction and reached a plateau concentration of mean 2.24 (SD 0.66) micrograms ml-1 after 5 min. The concentration of propofol in CSF showed a slower increase during induction and remained almost constant at 35.5 (19.6) ng ml-1 at 15-30 min after induction. The CSF concentration of propofol that we measured was 1.6% of the plasma concentration and consistent with the high protein binding of the drug in plasma.

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Automated solutions for manufacturing composite products based on prepreg often imply Automatic Fiber Placement or Automatic Tape Laying. These systems are generally associated with huge investments. For certain manufacturing applications it is interesting to investigate alternatives to find simpler and less costly automation. One example of an automated system could be the use of a standard industrial robot to pick single prepreg plies from an automated cutting machine and stack them to form a plane laminate. This paper is based on a case illustrating a product from the aircraft manufacturing industry. The case will demonstrate a pick and place concept on a general level and illustrate challenges that must be solved. The challenge selected to be the main focus for this paper is an automated process for backing paper removal. A literature review of different gripping technologies reveals several interesting technologies, and the most promising are tested for backing paper removal. The tests show that an automated removal process can be designed by using standard vacuum grippers in combination with mechanical clamping grippers. In order to lift the backing paper with a vacuum gripper an initial separation between the backing paper and prepreg is needed. This separation is most easily mechanically induced by bending the material. The proposed solution for automatic backing paper removal can be integrated in a manufacturing cell for manufacturing of the studied product.