Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2016; (13) 2: , 229-244 229 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Comparison of sunscreens Containing Titanium Dioxide Alone Or In AssociationWith Cocoa, Murumuru Or Cupuaçu Butters AbstractIngredients of natural origin may represent alternatives for formulating sunscreens, without compromising their effectiveness. The literature has shown the antioxidant potential of compounds existing in murumuru (Astrocaryum murmuru), cupuaçu (Theobroma grandiflorum) and cocoa (Theobroma cacao) butters that recommends further investigation. The objectives of this research were: (1) to develop bioactive photoprotective formulations containing cocoa, murmuru or cupuaçu butters in association with a physical sunscreen (titanium dioxide (TiO2)) and (2) determine the possible photoprotective activity of butters and their interactions with the sunscreen. Cocoa, cupuaçu and murumuru butter were individually associated to TiO2 in O / W emulsions. The anti-UVA and UVB efficacy in vitro was estimated by diffuse transmittance analysis in a Labsphere® UV2000S, using quartz plates and Transpore® tape to obtain the SPF (sun protection factor) and critical wavelength. Photoprotective formulations containing titanium dioxide and bioactive butters were obtained using Aristoflex® AVC and triglycerides of caprylic capric acid (GTCC). The SPF of the samples containing only TiO2 and formulations containing cocoa, murumuru or cupuassu butters associated with TiO2 ranged from 4 to 5. The critical wavelength values for these formulations ranged from 383.0 to 386.7 nm. The results indicated no increase in the SPF value for formulations containing vegetable butters. The critical wavelength values indicated their potential to absorb part of the UVA radiation.Keywords: titanium dioxide, bioactive butters, Theobroma cacao, Theobroma grandiflorum, Astrocaryum murumuru, in vitro SPF ResumoOs ingredientes de origem natural podem representar alternativas para formulação de protetores solares, sem que haja comprometimento de sua eficácia. A literatura tem indicado potencial antioxidante de compostos existentes nas manteigas de murumuru (Astrocaryum murumuru), cupuaçu (Theobroma grandiflorum) e cacau (Theobroma cacao) que necessitam de maior investigação. Os objetivos desta pesquisa foram: (1) desenvolver fotoprotetores bioativos contendo manteigas de cacau (Theobroma cacao), murumuru (Astrocaryum murumuru) ou cupuaçu (Theobroma grandiflorum (Willd. Ex. Spring) Schum) em associação com filtro solar físico (dióxido de titânio) e (2) determinar a possível atividade fotoprotetora das manteigas e suas interações com filtro solar. As manteigas de cacau, cupuaçu e murumuru foram associadas, individualmente, ao dióxido de titânio em emulsões O/A. A eficácia anti-UVA e UVB in vitro foi estimada por meio da análise de transmitância difusa realizada em Labsphere® UV2000S utilizando placas de quartzo ...