This article studies the social well-being of the families of the Tyumen Region (excluding the Khanty-Mansi Autonomous Area — Yugra and Yamalo-Nenets Autonomous Area). This article considers the theoretical approaches to the concept of “social well-being” presented in the Russian academic literature. The results of a sociological study conducted by the authors in 2020 are presented. The novelty of the research lies in highlighting the specifics of intraregional differentiation of the influence of factors influencing the social well-being of families. The main research method was a questionnaire survey, which allowed providing a quantitative description of the phenomenon under consideration. The construction of the research sample model was carried out taking into account the center-peripheral model, which implies the analysis of the data obtained in the context of various types of territories represented in the region. The volume of the quota sample of the study was 1,200 people — the representatives of regional families with children. The main goal of the article is to determine the general level of social well-being of regional families, as well as to show its specificity in such social-territorial communities as a large city, a small town, rural settlements of the central type and peripheral villages. The following were considered as the components of social well-being: satisfaction with various aspects of life; availability of social infrastructure facilities; assessment of the state of various spheres of life; problems that concern families, their needs. Based on the results of the analysis, it was concluded that in different types of settlements, the level and nature of social well-being change. This circumstance should become the object of close attention of the authorities implementing social policy. The authors noted the need to develop a social policy that takes into account the spatial characteristics of the region. At the same time, the research component is of great importance, which makes it possible to analyze the problems of families in a territorial context, and it is also important to develop clear criteria for the classification of socio-territorial communities, taking into account the tendencies of their changes over time.