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With the purpose of obtaining animalarial prodrugs, oxidized starch derivatives with antimalarials were prepared. Imines with one drug, sulfonamide or pyrimidine, were synthesized and submitted to usual spectrometric analysis, IR. UV and 1H NMR. With these analysis it was concluded that the following compounds were obtained: derivatives of sulfamethoxazole(ML7), sulfisoxazole(ML8) sulfameter(ML11) and trimethoprim(ML13). Only sulfameter derivative was curative in 100% of mice infected with Plasmodium berghei at 50 mg/weight kg dosis.

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Oxidized cellulose derivatives with sulfonamides and sulfone were synthesized in order to obtain antimalarials better than the now available. Derivatives of dapsone (ML14), sulfadiazine (ML17), sulfamethoxazole (ML18), sulfisoxazole (ML19), sulfamethoxypiridazine (ML20), sulfameter (ML22) were identified by usual spectrometric analysis (IR, UV, 1H‐NMR). Submitted to preliminar biological assay, only three compounds avoided the parasitemia on the 5th day after treatment and of these, sulfadiazine derivative showed activity on the 30th day after treatment of mice infected with Plasmodium berghei.