A simple and efficient procedure for the synthesis of ethyl 2-methylthio-and ethyl 2-benzylthio-6-methyl(aryl)-pyrimidine-4-carboxylates and their corresponding acid derivatives is reported. The products are obtained in good yields via the cyclocondensation reaction of ethyl 4-alkoxy-2-oxo-4-methyl(aryl)-but-3-enoates with 2-methylisothiourea sulfate or 2-benzylisothiourea hydrochloride, under mild, basic, aqueous conditions.

Efficient Syntheses of Ethyl 2-Methylthio-and Ethyl 2-Benzylthio-6-methyl-(aryl)pyrimidine-4-carboxylates and Their Carboxylic Acid Derivatives. -The simple preparation of the title compounds succeeds in moderate to good yields via cyclocondensation of 4-substituted ethyl 4-alkoxy-2-oxobut-3-eneoates with 2-methyl or 2-benzylisothiourea. -(ZANATTA*, N.; FORTES, A. S.; BENCKE, C. E.; MARANGONI, M. A.; CAMARGO, A. F.; FANTINEL, C. A.; BONACORSO, H. G.; MARTINS, M. A. P.; Synthesis 47 (2015) 6, 827-835, http://dx.

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