The field of structural DNA nanotechnology has undergone significant expansion in recent years as exciting new techniques and understanding have been developed, allowing for the design and assembly of complex and intricate two- and three-dimensional nanostructures. Many of these designed DNA motifs have found use in precise positioning of nanomaterials and thereby can aid in studies, reactions, and assembly of other nanostructures. This review discusses the history and progression of DNA-based nanofabrication with an emphasis on the use of DNA nanostructures for electronics applications.