Introduction. Pathological changes in the periodontium in people with diabetes mellitus, according to some data, are aggravated after orthodontic intervention, which dictates the need to carry out preventive measures, the effectiveness of which will determine the quality of orthodontic treatment. The aim of this study was to study the periodontal protective effect of two domestic antidisbiotic drugs containing plant extracts, vitamins, calcium and phosphorus salts. Methodology. The experiments were carried out on white Wistar rats, divided into 5 groups. The gums and periodontal bone tissue were isolated. The activity of urease, lysozyme and the content of hyaluronic acid was determined in the gingival homogenate, and the degree of dysbiosis was calculated. In the homogenate of the periodontal bone tissue, the activity of alkaline and acid phosphatases was determined, the mineralization index and the degree of mineralization, as well as the content of calcium and protein, were calculated. Results. The obtained results of our study have convincingly proved the pronounced periodontal protection efficacy of antidisbiotic drugs for oral applications of the plates "CM-2" and the drug Enoant polyphenols. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis, along with the manifestation of pronounced adaptogenic, antimicrobial and periodontal protective effects in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. Conclusion. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. The obtained results of the experimental study serve as the basis for the recommendation of the investigated complex, including the local application of plates with herbal extracts, vitamins, calcium and microelements, along with the systemic use of grape polyphenol concentrate, in an orthodontic clinic for patients with diabetes mellitus.

1 медицинская академия им. С. И. Георгиевского Крымского федерального университета им. В. И. Вернадского, Симферополь, Российская Федерация 2 Институт стоматологии и челюстно-лицевой хирургии Национальной академии медицинских наук, Одесса, Украина effecT of anTidisBioTic drugs on periodonTal Tissues of raTs WiTh diaBeTes melliTus afTer orThodonTic TooTh relocaTion demyanenko s. a. 1 , morozov a. l. 1 , morozova m. n. 1 , shabliy d. n. 1 , denga a. e. 2 1 medical academy named after s. i. georgievsky of V. i. Vernadsky crimean federal university, simferopol, russian federation 2 The institute of dentistry and maxilla-facial surgery, national academy of medical sciences, odessa, ukraine Целью данного исследования стало определение влияния ортодонтического перемещения зубов на состояние пародонта у крыс с экспериментальным сахарным диабетом и определение возможности предотвращения патологических изменений с помощью антидисбиотических средств. В опытах на белых крысах линии Вистар выделяли десну, костную ткань пародонта, а также получали сыворотку крови. В гомогенате десны определяли уровень биохимических маркеров воспаления, а в гомогенате костной ткани пародонта определяли активность щелочной и кислой фосфатаз, активность эластазы, а также содержание кальция и белка. Результаты исследований свидетельствуют о развитии системного воспаления, активации перекисного окисления липидов, воспаления и об усилении контаминации на деснах условно-патогенной микробиоты, развитии дисбиоза на фоне снижения антимикробной защиты в полости рта. Результаты дают основание рекомендовать применение исследованных антидисбиотических средств перед ортодонтическим перемещением зубов у пациентов с сахарным диабетом.

action of oral applications of soy isoflavons in rats after orthodontic operation on the background of experimental diabetes mellitus.