The aim: The aim of this study was to investigate disease-free and overall survival in patients with stage IIII A NSCLC after neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, and neoadjuvant chemotherapy. Materials and methods: For the study, 3 groups of 65 people were taken. All patients underwent radical surgery in the form of lobectomy, bilobectomy or pneumonectomy. All groups received 3 or 4 courses of neoadjuvant chemotherapy according to the scheme Docitaxel (Paclitaxel) and Cisplatin (Carboplatin), while groups II and III also received, respectively, neoadjuvant and adjuvant radiation therapy in the amount of 30 Gy to the chest and mediastinum. Survival was assessed using the Kaplan and Mayer scale. Results: 1. At a survival period of 6 months, the results of relapse-free survival in the NCRT and NCT groups do not differ. 2. From 12 months to 5 years, the highest recurrencefree survival rates are observed in the NHL group. 3. The overall five-year survival rate in the main group was 28.1±5.9%, in the NCT group - 10.4±3.8% and - 5.8±2.0% in the NCT + RT group. Conclusions: The best recurrence-free survival results are observed in the NHLT group. Also, the largest number of cases of molars morphological response, correlated with the highest survival rates, also occurs in the NHL group.

The aim: To study the survival rate and count the number of complications in groups with NCRT, NCT and NCT + adjuvant radiotherapy. Materials and methods: The studied patients were divided into three groups with a total number of 304 people, Patients who received neoadjuvant chemotherapy-149 people, who received neoadjuvant chemotherapy and adjuvant radiation therapy-90 people. Neoadjuvant chemoradiotherapy was performed in accordance with Cisplatin/Docetaxel or Carboplatin/Paclitaxel 4 Mg and simultaneous radiation therapy with a total radiation dose 30 gray with a single dose of 2 Mg. After neoadjuvant treatment, patients of all groups underwent radical surgery. It consisted of lobectomy, bilobectomy and pneumonectomy. Postoperative complications and the duration of stay in the clinic after surgery were studied. Survival was assessed on the Kaplan and Mayer scale. Results: The study analyzed the main results of treatment, which showed that the 5 years survival in the main group was 28.1±5.9 %, in the control groups-the first control group (neoadjuvant chemotherapy) - 10.4±3.8 % and the second control group (neoadjuvant chemotherapy and adjuvant radiation therapy) - 5.8±2.0 %, respectively. Conclusions: 1. The overall survival rate of patients receiving NCT compared to patients receiving neoadjuvant chemotherapy is higher than in the neoadjuvant chemotherapy group and 13 months higher than in the adjuvant radiation therapy group. 2. Patients who had the phenomenon of a complete morphological response have a significantly higher survival rate (45 and 39 months, respectively).