Introduction: Due to importance of surgeries for treatment of heart diseases, it is necessary to recognize surgical site infection and other Healthcare-Related Infections as the main post-surgical complications. Objective:  To analyze the association and correlation between clinical and propaedeutic variables with the prevalence of wound infection in patients undergoing cardiac surgery  Methodology:  Quantitative, analytical study with a retrospective approach. Data collection  was performed in the Medical Archive Sector of the Clinical Hospital of Uberlandia (HCU), using a previously structured instrument. Results:  A total of 453 medical records were evaluated, mainly masculine gender (n=313; 69.1%). A time patient hospital stays had a mean of 36.47±28.7days, surgical indication of myocardial revascularization (n=278; 61.4%). The rate of surgical wound infection (SWI) found was 19%. Correlation and clinical associations were: Time of surgery and left ventricle ejection fraction (LVEF) (r=0,10; p<0,05); time hospital stay and almost all echocardiographic variables, weight and height (p=0.01); Systolic blood pressure (SBP) and left ventricle posterior wall (LVPW) (r=0.16), LVEF (r=0.12) and intraventricular septum (r=0.13), (p<0.01); Diastolic blood pressure (DBP) and left ventricle posterior wall (LVPW) (r= 0.10; p<0.01). Conclusion: The study has hight potential to increase scientific evidences and improving  cardiovascular care, cardiovascular surgery field and prevention of healthcare-associated infections.