ObjectiveHypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are characterized by decreased density of arterioles and capillaries in the tissues, called rarefaction. Rarefaction significantly increases peripheral resistance which results in elevated blood pressure, leads to vessel damage and induction of inflammation. Therefore, we hypothesized that hypertension is associated with decreased serum concentration of physiological pro-angiogenic factors and concomitant increased production of angiogenesis inhibitors.Materials and Methods82 patients diagnosed with hypertension and 34 healthy volunteers were recruited to the study. Flow cytometry and enzyme-linked immunosorbent assay (ELISA) techniques were used to measure serum levels of the following cytokines: endostatin, vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), angiogenin, and basic fibroblast growth factor (bFGF).ResultsHypertensive patients were characterized by increased serum concentration of endostatin which is an anti-angiogenic factor. In addition, hypertension was associated with decreased levels of physiological pro-angiogenic mediators such as: angiogenin and bFGF. The hypertensive group was also characterized by elevated levels of CRP, VEGF and IL-8 that are the hallmarks of inflammation.ConclusionsPresented results show that hypertension is characterized by imbalance of pro-angiogenic and anti-angiogenic factors in the background of inflammation.

Objective: To evaluate the postoperative changes of the basic electrophysiological and psychophysical parameters in cochlear implant (CI) patients: the impedance of the electrode contacts, the electrically-evoked compound action potential (ECAP) thresholds and the T/C levels. Study Design and Setting: Retrospective case review in a quaternary otologic referral centre. Materials and Methods: Data on the impedance of the electrode contacts, the ECAP thresholds and the T/C levels were collected in 20 consecutive CI patients divided into 2 groups. Group 1 comprised 10 prelingually deaf children implanted before the age of 18 months, and group 2 comprised 10 postlingually deaf adults (average age of 58 years). All patients were users of the Nucleus 24RECA (Freedom, Contour advance off-stylet electrode) CI. Results and Conclusions: (1) The mid-portion and the apical electrodes showed a decrease in the impedance values between the 1st and the 6th postoperative months and stabilization in the later course. Impedance of the most basal electrodes grew during the first postoperative months and stabilized later on, but remained higher than the impedance of the mid-portion and the apical electrodes. (2) The neural response telemetry threshold values tended to decrease within the first 3 months after surgery to reach a plateau afterwards. (3) The behavioural threshold levels remained generally stable, except for the basal electrodes where a decrease could be observed. The hearing comfort levels showed an increase during the first 6 months of the implant use and remained stable afterwards.

IntroductionStandard procedures carried out at a stroke department in patients after a cerebral event may prove insufficient for monitoring hemodynamic indices. Impedance cardiography enables hemodynamic changes to be monitored non-invasively. The aim of the work was to describe hemodynamic parameters in patients with acute phase of ischemic and hemorrhagic stroke and to analyse the correlation between the type of hemodynamic response and long-term prognosis.Material and methodsThe 45 consecutive subjects with ischemic stroke and 16 with a hemorrhagic stroke were examined additionally with impedance cardiography during the first day of hospitalization. The heart contractility, pump performance, afterload and preload indices were recorded and calculated automatically and the data analyzed in terms of 6-month mortality.ResultsWe found a significant association between the systemic vascular resistance index, Heather index, stroke index, heart rate, systolic and diastolic and mean arterial blood pressure and mortality in patients with ischemic stroke (p = 0.002, p = 0.008, p = 0.012, p = 0.005, p = 0.007, p = 0.009, p = 0.002 respectively). Logistic regression analysis identified the thoracic fluid content as the most significant variable correlating with the non-survival of the patients with ischemic stroke and in the whole group (ischemic and hemorrhagic stroke). The significant parameters were also mean arterial pressure and stroke index in ischemic stroke (the correct answer ratio was 86.67%) and heart rate in the whole group (the correct answer ratio was 80.33%). There were no significant associations in hemorrhagic stroke.ConclusionsThe hemodynamic parameters correlate with long term prognosis in patients with ischemic brain stroke.

Objectives: Web information systems may serve as a diagnostic tool for the Internet users and they also support the epidemiological work of doctors and health care providers. As part of this study, a system has been created for detecting and calculating cardiovascular risk. The aim of this study has been the comparison of cardiovascular risk factors and calculated fatal cardiovascular risk in 2 periods of time: 2004-2009 and 2010-2015 in Poland, as determined via the Internet. Material and Methods: The "Ryzyko program" ("Risk program") is available on the website of the Medical University of Gdańsk. To assess the cardiovascular death risk in a 10-year period, the algorithm of the SCORE (Systematic Coronary Risk Evaluation) project was used and 30 402 results of the algorithm have been analyzed. Results: Over 30 402 webpage visitors entered the required data and received the outcome. More than 78% of the Internet users who had entered the data, received a recommendation for medical check-up. Significant differences between the data collected in 2004-2009 and 2010-2015 were noticed. Hypercholesterolemia prevalence (67.3% vs. 70.8%; p < 0.001), mean total cholesterol concentration in blood (5.60±1.65 mml/l vs. 5.66±1.35 mml/l; p < 0.001), prevalence of hypertension (36.6% vs. 35.3%; p = 0.039), mean systolic blood pressure (131.5±20.3 mm Hg vs. 132.6±18.0 mm Hg; p < 0.001), prevalence of declared smoking (30.7% vs. 26.5%; p < 0.001), declared diabetes mellitus (DM) (6.4% vs. 9.7%; p < 0.001), and declared coronary artery disease (CAD) (7.2% vs. 14.1%; p < 0.001), respectively. Conclusions: The prevalence of cardiovascular risk factors has changed during the observed period of time. Online automatic gathering of new data by "Ryzyko program" provides up-to-date observations. Int J Occup Med Environ Health 2017;30(3):499-510

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