Andy Eko Wibowo)ABSTRAK Senyawa 1-(2,5-dihidroksifenil)-(3-piridin-2-il)-propenon merupakan senyawa kalkon yang memiliki aktifitas antiinflamasi sebanding dengan ibuprofen dan aktifitas antioksidannya sangat kuat setara dengan quercetin. Senyawa ini telah disintesis menggunakan 2,5-dihidroksiasetofenon dan piridin-2-karbaldehida dengan metode radiasi microwave dan katalis K 2 CO 3 tanpa pelarut selama 4 menit. Dalam upaya memperoleh rendemen yang lebih baik, dilakukan penelitian dengan mengganti katalis, yaitu menggunakan katalis NaOH. Penelitian dilakukan dengan mereaksikan senyawa 2,5-dihidroksiasetofenon dan piridin-2-karbaldehida dengan variasi katalis NaOH sebesar 0-0,002 mol. Senyawa disintesis menggunakan kekuatan radiasi microwave sebesar 140 watt selama 4 menit. Setelah proses sintesis maka dilakukan perhitungan rendemen senyawa 1-(2,5-dihidroksifenil)-(3-piridin-2-il)-propenon untuk mengetahui massa katalis NaOH yang optimal dalam menghasilkan rendemen terbanyak. Berdasarkan hasil yang didapat, massa katalis optimum untuk sintesis senyawa 1-(2,5-dihidroksifenil)-(3-piridin-2-il)-propenon adalah 0,0010 mol dengan rendemen sebesar 13,23%.Kata kunci: 1-(2,5-dihidroksifenil)-(3-piridin-2-il)-propenon, kalkon, K 2 CO 3 , NaOH, microwave, optimasi. PHARMACY: Jurnal Farmasi IndonesiaABSTRACT 1-(2,5-dihydroxyphenyl)-(3-pyridine-2-yl)-propenone is a chalcone with antiinflammatory activity comparable to that ibuprofen and antioxidant activity equivalent to quercetin. This compound can be synthesized using 2,5-dihydroxyacetophenone and pyridine-2-carboxaldehyde with microwave radiation method and catalyst of K 2 CO 3 without any solvent in 4 minutes. To obtain the higher yield, the catalyst is replaced by NaOH.

GeMa CerMat is a movement launched in 2016, which is expected to achieve rational treatment in the wider community. To support this movement, the Indonesian Pharmacists Association launched DAGUSIBU (DA = dapatkan (Get), GU = gunakan (Use), SI = simpan (Store), and BU = buang (Dispose) of medicine) to educate the entire community to understand how to get good medicine, how to use medicine properly, how to store medicine properly and how to dispose of medicine properly. Based on observations to the head of Gampeng Pajangan Bantul hamlet, the community does not understand how to take medicine rationally for their relatives who take regular medicine and also do not understand how to manage the huge amount of medicine they get every month. Based on this evidence, the DAGUSIBU training was conducted to strengthen the understanding of rational drug use for the TP-PKK (Family Welfare Development Team) Gampeng hamlet, Triwidadi village, Pajangan Bantul. The TP-PKK in the hamlet consists of 25 health cadres and woman society village. At the end of the training session, the practice of destroying drugs was carried out. The results of the training showed a significant increase in understanding on DAGUSIBU after training. Evaluation was taken by giving pre-test and post-test according to DAGUSIBU. The DAGUSIBU guide book for Health cadres and the general public is given to TP-PKK at the end of the activity to help the community understand of DAGUSIBU and become a source of information on drug use.

1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound is a compound synthesized by reacting the pyridine-2-carbaldehyde and 2.5-dihydroxyacetophenone compound without solvent with K2CO3 (Potassium Carbonate) catalyst in the microwave. The 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound is a chalcone derivative compound substituted by two hydroxy groups on ring A and has 2-pyridyl groups on ring B. Chalcone is a secondary metabolite compound from the flavonoid group, which has several activities as anti-platelet, anti-bacterial, immunomodulator, anti-hyperglycemic, and anti-inflammatory. This study aims to determine the antibacterial effect of 1-(2.5-dihydroxifenil)-(3-pyridine-2-il)-propenone compound against Enterococcus faecalis and Escherichia coli bacteria. This study used TLC (Thin Layer Chromatography) and Melting Point Test to analyze the purity of 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound. Meanwhile, the test for antibacterial activity used a well diffusion method. Concentration variation for 1-(2.5-dihydroxifenyl)-(3-pyridine-2-il)-propenone compound as antibacterial in Escherichia coli were 0.25 mg/100 μl, 0.5 mg/200 μl, and 0.75 mg/300 μl. Meanwhile, the concentration variation for Enterococcus faecalis bacteria was 5%, 2.5%, 1.25% and was replicated three times. The results of the compound purity test using the melting point test and Thin Layer Chromatography (TCL) showed that the 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound was pure. The results of the antibacterial activity test for 1-(2.5-dihydroxiphenyl)-(3-pyridine-2-il)-propenone compound showed no zone of inhibition at each test concentration. In conclusion, the 1-(2.5-dihydroxifenyl)-(3-pyridine-2-il)-propenone compound did not have an antibacterial effect on Enterococcus faecalis and Escherichia coli bacteria.

Chalcone compounds and some n-hydroxychalcone compounds exhibit anti-inflammatory activity. Chalcone derivatives 1-(2,5-dihydroxyphenyl)-(3-pyridine-2-il)-propenone showed a stronger bond to the COX-2 enzyme than 1-(2,4-dihydroxyphenyl)-3-pyridine-2-il-prophenone, 2′,5′-dihydroxychalcone, 4-chloro-2′, 4′-dihydroxichalcone, and several NSAIDs when they were tested for molecular docking computing using MOE software. It shows that compounds 1-(2,5-dihydroxyphenyl)-(3-pyridine-2-il)-prophenone. Computationally have better anti-inflammatory activity. Synthesis of compounds was by reacting 2,5-dihydroxyacetophenone and pyridincarbaldehyde (without solvent, K2CO3 catalyst) under microwave radiation (radiation strength of P6 / equivalent to 41oC) within 4 minutes. The purification used ethanol washing: aquadest (10:90) and ethanol recrystallization. The structure of the synthesized compound was determined by mass spectroscopy, ultraviolet and visible (UV-Vis), infrared (IR), 1H-NMR, 13C-NMR, DEPT, and 2-dimensional NMR spectroscopy (HMQC, COSY, and HMBC). Anti-inflammatory activity test used rat foot edema method, which was induced by carrageenan. The structural elucidation showed that the compound synthesized was 1-(2,5-dihydroxyphenyl)-(3-pyridine-2-il)-propenone. The compound has a red color, a melting point of 190oC, and a purity of 94% by liquid chromatography. The compound had % DAI (Percentage of Anti-Inflammatory Power) of 50.05 ± 16,244 which was not significantly different from % DAI of ibuprofen (57.22 ± 20.134) (p> 0.05).

Abstrak Odong-Odong Apoteker, Simbol, dan Media Branding Eksistensi Apoteker di Masyarakat Indonesia dalam Rangka Gerakan Masyarakat Cerdas Sadar Obat (GEMACERMAT) adalah gerakan yang dilandasi oleh keterpurukan image apoteker dua tahun terakhir akibat berbagai kasus yang terjadi di Indonesia. Tujuan odongodong apoteker adalah menjadi simbol eksistensi dan peran apoteker di masyarakat. Metode yang digunakan adalah pembuatan odong-odong berbentuk apoteker memegang kapsul; mengubah lirik lagu anak-anak menjadi lirik seputar pengetahuan dasar obat yang harus diketahui masyarakat; dan memperkenalkan odong-odong sebagai maskot baru apoteker anggota IAI Cabang Bantul dan apoteker anggota IYPG Cabang Yogyakarta ketika penyelenggaraan kegiatan pengabdian masyarakat. Hasil pengabdian ini adalah odong-odong apoteker tercipta dengan berbagai lagu anak-anak yang telah diubah liriknya. Odong-odong apoteker pertama kali digunakan oleh IAI ketika melakukan penyuluhan obat antibiotik pada acara jalan sehat dalam rangka Hari Kemerdekaan Republik Indonesia ke-73 yang diselenggarakan oleh Karang Taruna Tanuditan Bantul. Odong-odong apoteker telah diletakkan di beberapa apotek milik apoteker anggota IYPG. Odong-odong apoteker menjadi tempat yang disukai anak-anak untuk bermain sekaligus menikmati lagulagu yang berisi pengetahuan seputar obat-obatan. Lagu-lagu tersebut diharapkan dapat masuk ke alam bawah sadar masyarakat dan secara tidak langsung mengedukasi mereka perihal penggunaan obat. Abstract Pharmacist Odong-Odong, Symbols, and Media Branding the Pharmacist's Existence in Indonesian Communities within the framework of the Drug Conscious Smart Society Movement (GEMACERMAT) is a movement based on the deterioration of the pharmacist's image in the last two years due to various cases in Indonesia. The goals of pharmacists odong-odong become symbols of the existence and role of pharmacists in society. The method used is making odongodong in the form of a pharmacist holding a capsule, turning children's song lyrics into lyrics about basic knowledge of medicine that the public must know and introducing odong-odong as the new mascot of the pharmacists of IAI BantulBranch members and pharmacists of IYPG members of the Yogyakarta Branch when they organizing community service activities. The result of this community service is that pharmacists odong-odong are created with various children's songs whose lyrics have been changed. The pharmacist odong-odong, was first used by the IAI when conducting antibiotic drug counseling at a healthy walk event in the framework of the 73rd Independence Day of the Republic of Indonesia organized by Karang Taruna Tanuditan Bantul. Odong-odong pharmacists have also been placed in several pharmacies belonging to IYPG member pharmacists. Pharmacists odongodong become a favorite place for children to play while enjoying a song that contains knowledge about medicine. The songs are expected to enter the subconscious of the community and indirectly educate the use of drugs.