Human papillomaviruses constitute the most widely spread sexually transmitted viral infection world-wide. In about 1% of the cases, a continuing HPV infection can lead to the appearance of precancerous conditions. In a subsequent carcinoma progression, different types of cancer can develop -cervical, rectal, penile, oral, throat, laryngeal, etc. More than 200 HPV types have been established, with at least 25 found in lesions in the oral cavity.The attention of specialists in the field has been focused on the association between HPVs and oral carcinogenesis. It is highly recommended that each patient with a suspected lesion in the oral cavity should be tested for HPV.

Epstein-Barr virus and Cytomegalovirus have different oral manifestations which could be presented in the oral cavity most commonly as non-specific oral ulcerations and lymphadenopathy. A lot of people acquire primary infection with Cytomegalovirus and if they later become immunosuppressed, such as human immunodeficiency virus (HIV), Cytomegalovirus is likely to become reactivated. We present a clinical case of a young man with multiple painful oral ulcerations with duration more than several years. The patient applied different types of local creams without significant results. After the clinical examination our recommendation was to investigate serum levels of EBV-IgG and CRP-IgG and HIV-1 and-2, complete blood count with differential (CBC), folic acid, CRP. The laboratory results revealed positive IgG antibodies against CMV and EBV, folic acid deficiency.

Epstein-Barr virus and Cytomegalovirus have different oral manifestations which could be presented in the oral cavity most commonly as non-specific oral ulcerations and lymphadenopathy. A lot of people acquire primary infection with Cytomegalovirus and if they later become immunosuppressed, such as human immunodeficiency virus (HIV), Cytomegalovirus is likely to become reactivated. We present a clinical case of a young man with multiple painful oral ulcerations with duration more than several years. The patient applied different types of local creams without significant results. After the clinical examination our recommendation was to investigate serum levels of EBV-IgG and CRP-IgG and HIV-1 and-2, complete blood count with differential (CBC), folic acid, CRP. The laboratory results revealed positive IgG antibodies against CMV and EBV, folic acid deficiency.