Acrylic resins dominated dentures technology for several decades. Due to their many disadvantages, new classes of resins, which promise better quality, constantly appear.Mechanical properties of acrylic resins, including fracture behaviour, water absorption and mechanical strength degradation caused by the exposure to saliva of classical heatcured acrylic resins compared to alternative urethane-based light-cured resins, were carried out. The allergy potential of acrylic resins was evaluated by in vivo and in vitro tests. New choices of resins, like thermoplastic injected resins, light-cured or milled highperformance polymers, with better properties compared to acrylics, suitable for dental applications are being presented.