The discomfort caused by exposure in the work process to occupational hazards generates. In this regard, this paper examines how the nuisances generated by technological processes influence the activity of workers and the legislative framework for jobs in which these occupational hazards exceed the allowed limits. In order to monitor the exposure to occupational hazards, the team of the Toxicology Laboratory performed determinations for the main occupational hazards existing in the work environment to the beneficiaries, the method of determining exposure to toxins being the direct method with measuring devices with numerical display, in time respectively, taking samples and analyzing them in the laboratory. The methods of analysis are in accordance with the legal provisions in force, using devices (metrological verified) and certified methods of analysis. Following the determination of noxious substances, specific risk assessments, in accordance with the legislation in force applicable to the jobs, in order to assess their impact on the health status of the staff, respectively the employment in special / special / normal working conditions, s -drew the following conclusions: periodic determinations of occupational toxins must be widely used to confirm or refute their existence in the workplace, permanent medical monitoring performed by occupational medicine practices, in conjunction with determinations of toxins, to establish traceability of occupational diseases with exposure to the susceptibility to its occurrence.