The neural tube defect prevalence found in this study was higher than the one described in international and Latin-American literature.

ResumoObjetivos: avaliar a prevalência e fatores associados aos defeitos de fechamento do tubo neural em recém-nascidos vivos e natimortos, na maternidade do Hospital das Clínicas da UFMG, entre 01/08/1990 e 31/07/2000.Métodos: trata-se de trabalho descritivo, baseado em banco de dados, seguindo normas do Estudo Colaborativo Latino-Americano de Malformações Congênitas (ECLAMC). São confeccionadas fichas dos recém-nascidos vivos e natimortos com anomalias congênitas, com descrição morfológica, resultados de necropsia, exames complementares, história familiar, social, da gravidez, e outros dados clínicos. Cada recém-nascido vivo malformado dá origem a um controle, do mesmo sexo, sem malformações. Os recém-nascidos vivos e natimortos com defeitos de fechamento do tubo neural, no período, foram classificados de acordo com o defeito apresentado e com a presença ou ausência de outros defeitos associados. Foram comparados sexo, peso, idade e paridade materna com os demais recém-nascidos vivos e natimortos do período. A análise estatística utilizou o programa EpiInfo 6.0.Resultados: a prevalência dos defeitos de fechamento do tubo neural foi de 4,73:1.000 partos (89:18.807), tendo sido maior entre os natimortos (23,7:1.000) que entre os recém-nascidos vivos (4,16:1.000), p<0,001. Os defeitos de fechamento do tubo neural foram mais freqüentes entre os recém-nascidos vivos de baixo peso (<2.500g), p<0,001, e menos freqüentes entre os filhos de multíparas (>3 gestações), p=0,007. Não houve associação com sexo ou idade materna. Entre os natimortos não houve associação com sexo, peso, paridade ou idade materna. Os defeitos de fechamento do tubo neural mais freqüen-tes foram mielomeningocele (47,2%), anencefalia (26,9%) e encefalocele (16,9%). Os defeitos se encontravam como anomalia isolada em 71,1% dos recém-nascidos vivos e 38,5% dos natimortos; faziam parte de uma síndrome em 9,2% dos recém-nascidos vivos e em 7,7% dos natimortos.Conclusão: a prevalência dos defeitos de fechamento do tubo neural foi maior do que a descrita na literatura internacional e na literatura latino-americana.J Pediatr (Rio J) 2003;79(2):129-34: anormalidades, defeitos do tubo neural, anencefalia, encefalocele, mielomeningocele. AbstractObjectives: to evaluate the prevalence and factors

Methods:A retrospective, database driven study, part of the LatinAmerican collaborative study of congenital malformations. Records were reviewed on all live born (LB) and stillborn (SB) infants with congenital heart diseases diagnosed by postnatal echocardiogram or by autopsy. Data on birth weight, sex, age and parity were collected for the LB and studied for associations. The statistical analysis employed Pearson's chisquare test and multinomial logistic regression.Results: During the period studied there were 29,770 births (28,915 LB and 855 SB). The prevalence of heart disease among the LB was 9.58:1,000 (277/28,915) while among SB the rate was 87.72:1,000 (75/ 855). Heart disease occurred isolated in 37.2% of LB cases and 18.7% of SB cases; was associated with anomalies of other organs and systems, but without a syndromic diagnosis in 31.4% of LB cases and 48.0% of SB cases; and in 23.1% of the LB cases and 32.0% of the SB cases the heart disease was a feature of a syndrome. Multivariate analysis demonstrated an association between heart disease and birth weight ≤ 2,500 g in all types of clinical presentation, between maternal age ≥ 35 years and heart disease in syndromic heart disease and between female sex and isolated heart disease. Conclusions:It was found a high prevalence, which is an alert to the medical significance of heart disease. There was association between birth weight ≤ 2,500 g and all forms of presentation, between increased maternal age and syndromic heart disease besides between female sex and isolated congenital heart disease. J Pediatr (Rio J). 2008;84(1):83-90:Congenital heart disease, prevalence, abnormalities, etiology. Artigo submetido em 28.09.07, aceito em 06.11.07.

The incidence was higher than the one described in the literature, probably, because it is a reference center in fetal medicine. The prenatal lesion involution rate was 32%, an intermediate proportion. There was good concordance between CT scan and anatomopathologic results. The polyhydramnios/hydrops were predictive of worst prognosis.

Objective: To estimate the prevalence rate and study the clinical presentation and associated factors of congenital heart diseases diagnosed at birth between August 1990 and December 2003, at the Maternity Unit of the Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil. Methods:A retrospective, database driven study, part of the Latin-American collaborative study of congenital malformations. Records were reviewed on all live born (LB) and stillborn (SB) infants with congenital heart diseases diagnosed by postnatal echocardiogram or by autopsy. Data on birth weight, sex, age and parity were collected for the LB and studied for associations. The statistical analysis employed Pearson's chi-square test and multinomial logistic regression.Results: During the period studied there were 29,770 births (28,915 LB and 855 SB). The prevalence of heart disease among the LB was 9.58:1,000 (277/28,915) while among SB the rate was 87.72:1,000 (75/855). Heart disease occurred isolated in 37.2% of LB cases and 18.7% of SB cases; was associated with anomalies of other organs and systems, but without a syndromic diagnosis in 31.4% of LB cases and 48.0% of SB cases; and in 23.1% of the LB cases and 32.0% of the SB cases the heart disease was a feature of a syndrome. Multivariate analysis demonstrated an association between heart disease and birth weight ≤ 2,500 g in all types of clinical presentation, between maternal age ≥ 35 years and heart disease in syndromic heart disease and between female sex and isolated heart disease. Conclusions:It was found a high prevalence, which is an alert to the medical significance of heart disease. There was association between birth weight ≤ 2,500 g and all forms of presentation, between increased maternal age and syndromic heart disease besides between female sex and isolated congenital heart disease.J Pediatr (Rio J). 2008;84(1):83-90: Congenital heart disease, prevalence, abnormalities, etiology.