Aqueous solutions of the achiral, monomeric, nucleobase mimics (2,4,6-triaminopyrimidine,T AP,and acyanuric acid derivative,C yCo6) spontaneously assemble into macroscopic homochiral domains of supramolecular polymers.T hese assemblies exhibit ah igh degree of chiral amplification. Addition of asmall quantity of one handedness of ac hiral derivative of CyCo6 generates exclusively homochiral structures.T his system exhibits the highest reported degree of chiral amplification for dynamic helical polymers or supramolecular helices.S ignificantly,h omochiral polymers comprised of hexameric rosettes with structural features that resemble nucleic acids are formed from mixtures of cyanuric acid (Cy) and ribonucleotides (l-,d -pTARC) that arise spontaneously from the reaction of TAPw ith the sugars. These findings support the hypothesis that nucleic acid homochirality was ar esult of symmetry breaking at the supramolecular polymer level.

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Fluorescent Pd(ii) and Pt(ii) complexes with anti-proliferative activity bearing 4-methylene-7-methoxycoumarin (MMC) and 2,6-diispropylphenyl (Dipp) substituted NHC/1,2,3-triazole hybrid ligands are described.