The presence of specific c-K-ras mutations is an indicator of tumor response in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy and surgery. Therefore, responding patients may be more amenable to less radical surgical procedures based on c-K-ras mutations.

Our results suggest that the determination of p53 is a factor in predicting tumor response in patients who undergo preoperative chemoradiation therapy for rectal adenocarcinoma.

No abstract

The concentration of trace elements in samples of both colorectal cancer tumors and normal tissues of a Mexican population were irradiated for 30 s and 4 h and their elemental content were measured by instrumental neutron activation analysis. Ca, Cu, Co, I, Mg, Se, Fe, Zn, Hg, Ba, and Cr were analyzed. Alterations in Co, Fe, I, and Ba were found in tumors with respect to normal tissues.

Fused pyridine derivativesFused pyridine derivatives R 0450 Synthesis and Evaluation of 9-Anilinothiazolo[5,4-b]quinoline Derivatives as Potential Antitumorals. -Five new title derivatives, cf. (III), (VI), (IX), (XI) and (XIII), combining the general substitution pattern of potent antitumoral acridines with a thiazoloquinoline template are prepared and preliminarily evaluated for their antitumoral activity. Compounds (IX), (XI) and (XIII) are synthesized by coupling properly substituted anilines to the novel thiazoloquinoline (VII). All derivatives demonstrate DNA binding in the nanomolar range. Derivative (IX) forms the tightest intercalation complex without correlation to its cytotoxic activity. On the other hand, (VI) forms the weakest and most extensive complexes with DNA being highly cytotoxic. -(RODRIGUEZ-LOAIZA, P.; QUINTERO, A.; RODRIGUEZ-SOTRES, R.; SOLANO, J. D.; LIRA-ROCHA*, A.; Eur.