ABSTRAK Pergeseran gaya hidup dan pola makan dimasa sekarang dapat menyebabkan terjadinya penyakit degeratif di usia lansia. Dimana saat ini prediksi bahwa populasi usia lebih dari 60 tahun akan meningkat sekitar 2–3 kali lipat pada tahun 2050, sehingga hal ini akan menyebabkan masalah kesehatan. Pemberdayaan Kelompok PKK Kelurahan Kauman Kota Malang dalam Pemanfaatan Bunga Telang Sebagai Bahan Pembuatan Teh Herbal. Adanya pemberian edukasi tentang manfaat teh herbal pada kader PKK dengan menggunakan zoom, maka kesehatan tetap terjaga dengan baik. Metode pelaksanaan yang digunakan meliputi 3 kegiatan: Tahap persiapan: melakukan pendekatan, persiapan bahan dan alat yang digunakan untuk pembuatan sediaan teh herbal; Tahap pelaksanaan: memberikan edukasi kesehatan dan pelatihan terkait manfaat, cara penyajian, dan penyebaran video pembuatan teh herbal. Tahap evaluasi dilakukan terhadap apresiasi grup. Hasil dari pengabdian dapat berjalan baik dan lancar sesuai dengan yang telah dijadwalkan, prosentase dengan nilai rata-rata untuk peningkatan pengetahuan terkait edukasi sistem organ 83,45%; manfaat, khasiat bunga telang 85,95% dan pelatihan cara pembuatan teh herbal 81,10% dengan menggunakan google form. Kesimpulan tujuan untuk mengangkat manfaat tanaman herbal dari simplisia bunga telang sebagai bahan dasar sediaan the herbal yang aman untuk lansia dimasa pandemi covid 19. Kata Kunci : teh herbal; antioksidan; penyakit degenerative; lansia; bunga telang ABSTRACTShifts in lifestyle and eating patterns today can cause degenerative diseases in the elderly. Where it is currently predicted that the population aged over 60 years will increase by about 2-3 times by 2050, so this will cause health problems. Empowerment of PKK Group in Kauman Village, Malang City in the Utilization of Telang Flowers as Ingredients for Making Herbal Tea. The existence of providing education about the benefits of herbal tea to PKK cadres by using zoom, then health is maintained properly. The implementation method used includes 3 activities: Preparation stage: approach, preparation of materials and tools used for the manufacture of herbal tea preparations; Implementation stage: providing health education and training related to the benefits, presentation methods, and video distribution of herbal tea making. The evaluation stage is carried out on group appreciation. The results of the service can run well and smoothly according to what has been scheduled, the percentage with the average value for increasing knowledge related to organ system education is 83.45%; benefits, the efficacy of the telang flower is 85.95% and training on how to make herbal tea 81.10% using the google form. The conclusion of the goal is to raise the benefits of herbal plants from telang flower simplicia as a basic ingredient for safe herbal tea preparations for the elderly during the covid 19 pandemic. Keywords: herbal tea; antioxidant; degenerative diseases; elderly; butterfly flower

ABSTRAKKegiatan Program Kemitraan Masyarakat ini diawali dengan pengkajian awal terhadap keadaaan di lapangan. Tanaman Pegagan (Centella asiatica) sering digunakan hanya sebagai penutup tanah, Pengkajian awal didapatkan kurangnya pengetahuan masyarakat kelurahan Kauman atas keberadaan dan manfaat pegagan ditandai dengan kurang optimal pengolahan pegagan dalam kosmetik dan obat kulit. Dengan mempertimbangkan potensi pegagan yang besar dalam segi kesehatan, program kepada masyarakat yang bertujuan pemberian edukasi mengenai manfaat pegagan, pengolahan dalam pembuatan face mist sebagai antioksidan dan pelembab kulit lansia. Adanya pemberdayaan terhadap anggota PKK diharapkan nantinya meningkatkan upaya pencegahan dalam mengatasi permasalahan kulit saat menjelang lansia. Maka peningkatan derajat kesehatan khususnya mengenai kulit saat menjelang lansia dapat teratasi dengan pemanfaatan pegagan (Centella asiatica), yang mempunyai manfaat sebagai antioksidan dan pelembab pada sediaan face mist pada kulit. Berkenaan dalam situasi pandemi maka pelaksanaan dilakukan dalam jaringan (daring) dengan menggunakan media zoom dan dilakukan evaluasi dengan metode pre-test dan post test. Hasil post test yang dilakukan dengan nilai rata-rata 83 dapat menjawab pertanyaan dengan benar jika dibandingkan dengan pre test dimana hanya nilai rata-rata 41. Hal ini menunjukkan bahwa pengetahuan anggota PKK Kelurahan Kauman Kota Malang telah meningkat setelah dilakukannya pemberdayaan melalui kegiatan pengabdian kepada masyarakat ini. Kata kunci: pegagan; face mist; Ibu PKK; lansia. ABSTRACTThis activity begins with an initial assessment of the situation in the field. The gotu kola plant (Centella asiatica) is often used only as a ground cover. The initial assessment found that there was a lack of knowledge of the people of the Kauman village on the benefits of gotu kola, which was marked by the less than optimal processing of gotu kola in cosmetics and skin medicine. Taking into account the great potential of gotu kola in terms of health, this program aimed at providing education about the benefits of gotu kola, processing in making face mist as an antioxidant and moisturizing the skin of the elderly. The existence of empowerment of PKK members is expected to increase prevention efforts in overcoming skin problems when approaching the elderly. So the improvement of health status, especially regarding the skin when approaching the elderly, can be overcome by the use of gotu kola (Centella asiatica), which has benefits as an antioxidant and moisturizer in face mist preparations on the skin. With regard to the pandemic situation, the implementation is carried out online (online) using zoom media and evaluation is carried out using pre-test and post-test methods. The results of the post test carried out with an average value of 83 can answer the questions correctly when compared to the pre test where only the average value is 41. This shows that the knowledge of PKK members in Kauman Village, Malang City has increased after empowerment through community service activities. to this society. Keywords: gotu kola plant; face mist; PKK members; elderly.

Introduction: This Community Service Activity begins with an initial assessment of the situation in the field. The initial study found problems from the results of a preliminary study conducted by interviewing elderly people who experienced insomnia in Kauman Village, Malang City, as many as 10 elderly people who experienced insomnia. Objective: This community service activity aims to provide knowledge related to making aromatherapy candles. Method: The implementation of this activity begins with the process of evaluating the level of knowledge and attitudes of PKK cadres regarding the prevention stress and how to make of aromatherapy candles by conducting a pre-test using a questionnaire. Then, the team provided education about the prevention stress and how to make of aromatherapy candles by using appropriate media. This activity was carried out using the transfer & sharing method of knowledge by using aids of audiovisual media and leaflets, and practice of making aromatherapy candles. Besides being open for discussion sessions, questions, and answers related to aromatherapy candles. Result: The success of the PkM program can be seen from this. This can be seen from the average increase in understanding ability to 33.57%. The pretest average value of the 23 PkM participants was 65.2% and after participating in the PkM activities the understanding of the activity participants obtained the posttest average value of the 23 PkM participants was 98.3%. Then from the results of the evaluation of the skills of the participants, a value of 86.67 was obtained and could be categorized as skilled. Conclusion: We concluded that providing education related to how to make aromatherapy candles could increase people's knowledge and attitudes.

Mangrove plants are known to produce various secondary metabolites (SMs) such as polyisoprenoids (dolichol and polyprenol), emodin, and luteolin to show anticancer, anti-inflammatory, antiviral, and antibacterial activities. This study aimed to predict the multiple activities of the SMs of mangroves based on several enzymes that utilize the in silico method. The properties of absorption, distribution, metabolism, excretion, and toxicity for emodin, luteolin, polyprenol C80, dolichol-17 (C85), and dolichol-20 (C100) displayed variation. Prediction for Lipinski's rule showed that emodin and luteolin have lower molecular weight than polyprenol C80, dolichol C85, and dolichol C100. Emodin and luteolin were further docked with cyclooxygenase-2, beta-lactamase, CYP450-dependent 14-alpha demethylase, 3C-like protease, and P-glycoprotein as protein targets using the Molegro Virtual Docker Ver.5.5 approach. In comparison to celecoxib, ketoconazole, clavulanic acid, remdesivir, and verapamil, emodin and luteolin had higher rerank scores. The quantitative structure-property relationships depicted that the electronic parameter, highest occupied molecular orbital (E HOMO ), was the physical chemistry parameter that influenced the total clearance. The present findings emphasized that emodin and luteolin from the SMs of mangroves have multiple activities as potent inhibitors of cancer cells and bacterial infections.

Anthranilamide derivatives exhibit anti-inflammatory, antipyretic, antibacterial, antiangiogenic, and anticoagulant properties. With an early in silico examination of its analgesic capabilities, this study aimed to generate a novel anthranilamide molecule by altering 2-Benzamido-N-Benzylbenzamide. Modification of anthranilamide with 1/2/3-chloro benzoyl chloride by acylation resulted in the design, synthesis, characterization, and research of the analgesic effects of 2-benzamido-N-benzoylbenzamide derivatives. 2-(2-chlorobenzamido)-N-(2-chlorobenzoyl)benzamide, 2-(3-chlorobenzamido)-N-(3-chlorobenzoyl)benzamide, and 2-(4-chlorobenzamido)-N-(4-chlorobenzoyl)benzamide were prepared. The nucleophilic acyl substitution reaction method was used to prepare these three chemicals by interaction with anthranylamide and benzoyl chloride molecules. Melting point and thin-layer chromatography were used to check the purity of the synthesis fi ndings. The structure was confi rmed by UV-Vis and infrared spectrophotometry.