Pharmacovigilance plays an vital role in modern technology which helps in monitoring and assessing the high-quality of Drugs, detection and stopping of any unfavorable outcomes of drugs. Pharmacovigilance starts with case processing: this involve safety data collection and coding, case management reporting and submission. In case of clinical trial, it is the investigator or in case of post-marketing trial, it is either the physician or the prescriber or the patient himself who reports the adverse event or any drug-related problem. Pharmacovigilance case processing helps to get clear information regarding the drug and outcomes by using various software technologies. Arugs database, cemflow, vigibase and ICSR are few software used nowadays. Case processing helps to monitor and track all serious adverse events, and medically significant ADRs and other medical related product information followed by timely processing and reporting of such information according with company and regulatory reporting.

When stress affects the body it interferes with physiological functions of the body and other normal functions such as physical and emotional behaviors of the individual and this is associated with the cause of depression, anxiety mental disorders. Here comes the cause of irrational responses of the body system. The different forms of irrational response are the symptoms for depression. Severe depression with significant effect on day to day life is considered as disability. There are so many synthetic medicines that are used to treat depressions they are playing a prominent role in this civilized world with so many adverse effects, in the other hand natural/ herbal medicines are also playing a crucial role with minimum to zero side effects.One of the main causes of depression is oxidative stress, which is a type of imbalance between the production of reactive oxygen species and the anti-oxidant defensive system.

Portulaca quadrifidaL. (PQ) having the phytochemicals like Alkaloids, flavonoids, Saponins, tannins, glycosides, carbohydrates, aminoacids, triterpenoids. The present study was performed to evaluate the antioxidant and anti-inflammatory activities by using acetic acid induced vascular permeability model in mice & acetic acid induced colitis in rats significantly.  PQ (100 mg/kg, p.o.) presented a significant anti-inflammatory activity towards acetic acid induced vascular permeability model in mice in comparison to Diclofenac sodium(10 mg/kg, s.c.) and acetic acid induced colitis in rats in comparison to 5-ASA. Our findings suggest that, PQ contains potential antioxidant and anti-inflammatory compounds which will aid us to conduct bioactivity guided isolation & characterization of leading compounds in due course.