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During this covid-19 pandemic, a few cases of vertical transmission of severe acute respiratory syndrome coronavirus-2 from mothers to the fetus have been documented. Anti-SARS CoV-2 antibodies mediated multisystem inflammatory response syndrome (MIS-C) is known phenomenon in children. With this case report, we aim to demonstrate the evidence of fetal inflammatory response syndrome (FIRS) associated with anti-SARS CoV-2 antibodies in a premature neonate presenting with respiratory distress, seizures and shock in initial hours of life. The infant was RTPCR negative for covid-19, but positive for anti-SARS CoV-2 antibodies with raised inflammatory markers, suggestive of systemic inflammatory response syndrome. A comprehensive workup for other infectious pathogens also came up negative. Baby received IvIg and steroids and recovered completely. We believe that this systemic inflammation occurred due to antenatal exposure to the covid-19 virus and that more such instances will emerge in future.Baby's perfusion improved gradually over 48 hours

We present a case of a newborn with congenital absence of skin in both feet, dystrophic nails in both the lower limbs and who shortly after birth developed bullae and erosions in hands, ears, buttocks and mouth. With these findings, the diagnosis of Bart syndrome was made. Bart syndrome is a clinical diagnosis characterized by triad of the localized absence of the skin present at birth, epidermolysis bullosa (EB), lesions of the mouth and mucosa, and disfigured nails. Combination of absence of skin i.e. aplasia cutis congenita (ACC) and with simplex, junctional, or dystrophic types of epidermolysis bullosa (EB) is classified as type six ACC which is a very rare clinical condition and very few cases are available in literature and this case is fifth from India.

Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has demanded world’s attention. Though this disease affects all age groups, for reasons unknown at this time, neonates and children seem to be at a lower risk of severe infection. We report the first case of neonatal SARS CoV-2 encephalitis in Pune, India and review the related published articles. A 4-day-old, previously healthy, full-term neonate was hospitalized for poor feeding and repeated episodes of focal convulsions since 104 h of life. Keeping in mind the rampant community transmission, SARS-CoV-2 rapid antigen detection and polymerase chain reaction testing was done, where both turned out to be positive. There were elevated inflammatory markers, cerebrospinal fluid pleocytosis, and acute splenial lesions in the magnetic resonance imaging of the brain consistent with neonatal SARS CoV-2 encephalitis. The baby recovered completely with no recurrence and was discharged home in 2 weeks.