Isoindolinones are the core structures of many natural products, drug molecules and it is useful in material science as fluorescent probe and synthetic dyes. Fused analogue of this blending lactam...

Herein, we report one-pot Cu(I) catalyzed open flask synthetic strategy of 3-substituted N-pyridinyl isoindolinones from alkyl (E)-3-(2-formylphenyl)acrylate by oxidative amidation and intramolecular aza-Michael reaction using cheap air stable Cu(I) single catalyst. We have also established a synthetic route of Naryl substituted isoindolinones with acid-amine coupling reaction of (E)-2-(3-alkoxy-3-oxoprop-1-en-1-yl)benzoic acid followed by aza-Michael reactions. Unexpected synthetic route of N-(1H-inden-1-yl)pyridin-2-amine derivatives have been documented from the same precursors using Cu(I) catalyst.

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We have reported a one-pot two step methodology for the synthesis of highly condensed pyrrolo[1,2-a][1,4]benzodiazepines by modified Pictet–Spengler reaction.

Ammonium thiocyanate promoted simple, rapid and eco-friendly neat synthesis of isothiazoles has been developed for the first time. It is noteworthy that an instantaneous valuable synthetic route of β-enaminones has...