Deep seated residual infection following abdominal surgery is a therapeutic challenge. Administering antibiotics based on culture and sensitivity reports may not yield satisfactory results in all cases. Exact anatomical features need to be ascertained by imaging before deciding further course of treatment. Communication with ductal and luminal components of the gastrointestinal tract need to be ruled out before commencing osmotic debridement methodology. A combination of hypertonic saline and hydrogen peroxide irrigation followed by negative suction or vacuum treatment helps in obliteration and healing of deep seated infections. A case of a deep seated abscess cavity communicating with exterior managed by osmotic debridement and vacuum therapy is presented along with a brief review of literature.
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